{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:59:14Z","timestamp":1778788754004,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08362 & 16K19080"],"award-info":[{"award-number":["15K08362 & 16K19080"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The signalling lymphocytic activation molecule family member 8 (<jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8)\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>353 is a member of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>2 family of proteins. Its ligand has not been identified. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 is expressed by macrophages and suppresses cellular functions. No study has yet explored <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 expression or function in human mastocytosis, which features oncogenic <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\u2010mediated proliferation of human mast cells. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 protein was expressed in human mastocytosis cells, immunohistochemically. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 expression was also evident in the human mast cell lines, <jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>1.2 (expressing oncogenic <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>2 (expressing wild\u2010type <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>) cells. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 knock\u2010down significantly reduced the <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\u2010mediated growth of <jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>1.2 cells but not that of <jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>2 cells. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 knock\u2010down <jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>1.2 cells exhibited significant attenuation of <jats:styled-content style=\"fixed-case\">SHP<\/jats:styled-content>\u20102 activation and oncogenic <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\u2010mediated <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RAF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content> signalling. An interaction between <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">SHP<\/jats:styled-content>\u20102 was confirmed in <jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>1.2 cells and all pathological mastocytosis specimens examined (19 of 19 cases, 100%). Thus, <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 is involved in oncogenic <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\u2010mediated <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RAF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content> signalling and the subsequent growth of human neoplastic mast cells mediated by <jats:styled-content style=\"fixed-case\">SHP<\/jats:styled-content>\u20102. <jats:styled-content style=\"fixed-case\">SLAMF<\/jats:styled-content>8 is a possible therapeutic target in human mastocytosis patients.<\/jats:p>","DOI":"10.1111\/exd.13523","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T16:57:13Z","timestamp":1520009833000},"page":"641-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>SLAM<\/scp> family member 8 is involved in oncogenic <scp>KIT<\/scp>\u2010mediated signalling in human mastocytosis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8160-0267","authenticated-orcid":false,"given":"Akihiko","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-8976","authenticated-orcid":false,"given":"Tatsuki R.","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyuki","family":"Ueshima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141651"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.9.5675"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102620"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121968"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:34:2:97"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-078097"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10560"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116761"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.204"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00238"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900552"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902450"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1886"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0450"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0199"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12741"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1050"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101626"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00359.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00343-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90050-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710468105"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth947"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375873"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049052"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2177"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.5840"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2485"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050449"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Fexd.13523","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:24:02Z","timestamp":1694895842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/exd.13523"],"URL":"https:\/\/doi.org\/10.1111\/exd.13523","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2018-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}