{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:19:07Z","timestamp":1788783547487,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prognostic biomarkers for patients with melanoma after lymph node resection are of clinical relevance and could thus enable the identification of patients who therefore would most benefit from adjuvant treatment. The aim of this work was to determine, using an in vitro model, whether immune\u2010related biomarkers, such as <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\u2010class I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, melanoma\u2010associated antigens, <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1, could also be relevant to predict the risk of relapse of patients with stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> melanoma after lymph node resection. We established tumor cell lines from metastatic lymph nodes of 50 patients with melanoma. The expression of investigated biomarkers was determined on untreated and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 treated melanoma cell lines using flow cytometry. Among the selected biomarkers, the <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3\u2010induced expression of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 and <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>1 was associated with an increased risk of relapse (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013, respectively) and was also associated with death for <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0005). In the future, this immunologic signature could permit the identification of patients at higher risk of relapse and justifying an adjuvant treatment using immunotherapy.<\/jats:p>","DOI":"10.1111\/exd.13526","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T16:42:36Z","timestamp":1520268156000},"page":"647-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["PD\u2010L1 expression by tumor cell lines: A predictive marker in melanoma"],"prefix":"10.1111","volume":"27","author":[{"given":"Anne C.","family":"Knol","sequence":"first","affiliation":[{"name":"Centre de recherche en Canc\u00e9rologie et Immunologie Nantes\u2010Angers [CRCINA] Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale [INSERM] INSERM1232 Universit\u00e9 de Nantes Universit\u00e9 d'Angers CHU Nantes  Nantes 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