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Although extensively studied in muscle physiology, little is known about the function of myosins in mammalian skin. As part of the Sanger Institute Mouse Genetics Project, we have identified a role for <jats:italic>Myo10<\/jats:italic> in pigmentation, with a phenotype unlike those of <jats:italic>Myo5a<\/jats:italic> or <jats:italic>Myo7a<\/jats:italic>. Adult mice homozygous for a disrupted <jats:italic>Myo10<\/jats:italic> allele on a C57BL\/6N background displayed a high degree of penetrance for white patches on their abdomen and dorsal surface. Forepaw syndactyly and hind paw syndactyly were also observed in these mice. Tail epidermal wholemounts showed a complete lack of melanocytes in the hair follicles and interfollicular epidermis. <jats:italic>Myo10<\/jats:italic> has previously been implicated in human pigmentation. Our current study reveals involvement of <jats:italic>Myo10<\/jats:italic> in murine skin pigmentation.<\/jats:p>","DOI":"10.1111\/exd.13528","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T17:20:42Z","timestamp":1520356842000},"page":"391-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Myosin 10 is involved in murine pigmentation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-7424","authenticated-orcid":false,"given":"Kifayathullah","family":"Liakath\u2010Ali","sequence":"first","affiliation":[{"name":"Centre for Stem Cells &amp; Regenerative Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-1975","authenticated-orcid":false,"given":"Valerie E.","family":"Vancollie","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Genome Campus  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Centre for Stem Cells &amp; Regenerative Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-4530","authenticated-orcid":false,"given":"Christopher J.","family":"Lelliott","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Genome Campus  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-5154","authenticated-orcid":false,"given":"Fiona M.","family":"Watt","sequence":"additional","affiliation":[{"name":"Centre for Stem Cells &amp; Regenerative Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.040667"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3248"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-9-r196"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1136"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02726"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.187286"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-159046"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186882.114"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22077"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00759.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2669"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.06.023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb830"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089789"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2406"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01226-09"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602443103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.03.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800861"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.13528","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:36:13Z","timestamp":1694345773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,24]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/exd.13528"],"URL":"https:\/\/doi.org\/10.1111\/exd.13528","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,24]]},"assertion":[{"value":"2018-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}