{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:34:28Z","timestamp":1791588868789,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    ) is characterized by chronic, eczematous, severe pruritic skin lesions caused by skin barrier dysfunction and T helper (Th)2 cell\u2010mediated immunity. Interleukin (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    )\u201031 is a potent pruritogenic cytokine primarily produced by Th2 cells. Both\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 transgenic mice and wild\u2010type mice treated with\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 exhibit\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    \u2010like skin lesions and scratching behaviour.\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 receptor \u03b1\u2010chain (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031\n                    <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                    ) is also expressed in peripheral nerves and epidermal keratinocytes, and the roles of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 on pruritus and skin barrier have been investigated. Recently, an anti\u2013\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 receptor antibody was shown to significantly improve pruritus in\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    patients. This review focuses on\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031 and\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201031\n                    <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>\n                    in\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/exd.13533","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T21:42:34Z","timestamp":1520631754000},"page":"327-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Interleukin\u201031 and interleukin\u201031 receptor: New therapeutic targets for atopic 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