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Not only does <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> exert both tropic and trophic effects in a wide range of tissues, but it is also expressed in human skin and hair follicles and regulates multiple complex cutaneous functions, including keratin expression and hair growth. Despite several clinical indications that <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> may also play a role in sebaceous gland (SG) biology, the effects of <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content> function have received little attention. In this Viewpoint essay, we argue that <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> may be a sebotrop(h)ic hormone and could represent a novel therapeutic target in human dermatoses affecting the <jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content>. We provide preliminary evidence in support of this hypothesis (based on findings in human skin organ culture) and chart the major open questions in <jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content> biology and pathology from a <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> research perspective. We close by delineating how these questions can be experimentally addressed so as to identify new therapeutic strategies that are either sebogenic or sebostatic, for example in the management of acne and cutaneous ageing.<\/jats:p>","DOI":"10.1111\/exd.13545","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T07:26:49Z","timestamp":1522135609000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prolactin as a candidate sebotrop(h)ic hormone?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-2784","authenticated-orcid":false,"given":"Ewan A.","family":"Langan","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Luebeck  Luebeck Germany"},{"name":"Dermatology Research Centre NIHR Manchester Biomedical Research Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Hinde","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre NIHR Manchester Biomedical Research Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre NIHR Manchester Biomedical Research Centre University of Manchester  Manchester UK"},{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_15_2_1","volume-title":"Klinikleitfaden Dermatoligie","author":"Dirschka T.","year":"2011"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13231"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.016"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701729895"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12889"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.97.3.463"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12836"},{"key":"e_1_2_15_9_1","first-page":"101","volume":"75","author":"Kealey T.","year":"1997","journal-title":"Methods Mol. 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