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Epidermal\u2010dermal attachment requires <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>17 expression at the hemidesmosomes of the epidermal basement membrane zone because congenital <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>17 deficiency leads to junctional epidermolysis bullosa and acquired autoimmunity to <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>17 induces bullous pemphigoid. Recently, in addition to facilitating epidermal\u2010dermal attachment, <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>17 has been reported to serve as a niche for hair follicle stem cells, to regulate proliferation in the interfollicular epidermis and to be present along the non\u2010hemidesmosomal plasma membrane of epidermal basal keratinocytes. This review focuses on the physiological properties of <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>17 in the epidermis, its role in maintaining stem cells and its association with signalling pathways. We propose possible solutions to unanswered questions in this field.<\/jats:p>","DOI":"10.1111\/exd.13550","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T15:34:09Z","timestamp":1522510449000},"page":"1135-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Life before and beyond blistering: The role of collagen <scp>XVII<\/scp> in epidermal physiology"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-6366","authenticated-orcid":false,"given":"Ken","family":"Natsuga","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Nishie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3902"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117785"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0995-83"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.136.4.1231","volume":"136","author":"Labib R. 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