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The challenge was to establish an effective therapy to enhance tissue healing by the injection of a mixture of peripheral blood mononuclear cells (PB\u2010MNCs) and platelet\u2010rich plasma (PRP) into a skin autograft area. This new perioperative biotechnological approach enriches PRP with the effects of PB\u2010MNCs. It offers a novel advanced strategy that could become an ideal biologic blood\u2010derived therapy, whose components are entirely autologous and produced by a protocol independent by the operator.<\/jats:p>","DOI":"10.1111\/exd.13552","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T15:37:21Z","timestamp":1522510641000},"page":"795-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preliminary observations of a new approach to tissue repair: Peripheral blood mononuclear cells in platelet\u2010rich plasma injected into skin graft area"],"prefix":"10.1111","volume":"27","author":[{"given":"Catuscia","family":"Orlandi","sequence":"first","affiliation":[{"name":"Intensive Care Dermatology and Burn Center Regional Skin Bank of Emilia\u2010Romagna and Cell Factory Bufalini Hospital  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bondioli","sequence":"additional","affiliation":[{"name":"Intensive Care Dermatology and Burn Center Regional Skin Bank of Emilia\u2010Romagna and Cell Factory Bufalini Hospital  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-0412","authenticated-orcid":false,"given":"Michela","family":"Venturi","sequence":"additional","affiliation":[{"name":"Intensive Care Dermatology and Burn Center Regional Skin Bank of Emilia\u2010Romagna and Cell Factory Bufalini Hospital  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Melandri","sequence":"additional","affiliation":[{"name":"Intensive Care Dermatology and Burn Center Regional Skin Bank of Emilia\u2010Romagna and Cell Factory Bufalini Hospital  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/532519"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb9010010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/THS10-11-0720"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-016-1292-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070051"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_2_8_8_1","first-page":"143","volume":"27","author":"Nami N.","year":"2016","journal-title":"Platelets"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22183"},{"key":"e_1_2_8_10_1","first-page":"3532","volume":"13","author":"Nurden A. 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