{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:18:11Z","timestamp":1759814291005,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602745"],"award-info":[{"award-number":["81602745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130031"],"award-info":[{"award-number":["81130031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic multifactorial disease and is considered to be strongly associated with the major histocompatibility complex (<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>) region. We have discovered an independent, novel and susceptible psoriasis risk <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> loci, rs9266150; <jats:italic>P<\/jats:italic>\u00a0=\u00a04.52\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup> for the first time. In this study, we aimed to verify the relationship between the susceptible locus and the subphenotypes of psoriasis vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), including geographic location, gender, age of onset, family history and present skin lesion types (chronic plaque and guttate). To investigate the distribution and association of the rs9266150 gene with clinical phenotypes of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> in Chinese Han population, we conducted an analysis in case\u2010control and case\u2010only subjects in the 9906 controls and 8744 cases by <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> targeted sequencing stratified analysis in this study. Significant associations were found with a northern geographic location in the case\u2010only (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.97\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>) and the subphenotype\u2010control analyses (<jats:italic>P<\/jats:italic>\u00a0=\u00a05.57\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>), males in the case\u2010only (<jats:italic>P<\/jats:italic>\u00a0=\u00a04.77\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>) and the subphenotype\u2010control analyses (<jats:italic>P<\/jats:italic>\u00a0=\u00a07.31\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>), and guttate psoriasis in the case\u2010only (<jats:italic>P<\/jats:italic>\u00a0=\u00a04.08\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>) and the subphenotype\u2010control analyses (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.27\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>). There were no significant differences observed between the age of onset (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.062, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.9725\u20101.16, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.8\u00a0\u00d7\u00a010<jats:sup>\u22121<\/jats:sup>) and the family history of psoriasis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.981, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.9048\u20101.064, <jats:italic>P<\/jats:italic>\u00a0=\u00a06.43\u00a0\u00d7\u00a010<jats:sup>\u22121<\/jats:sup>). The recessive model provided the best fit for rs9266150 (<jats:italic>P<\/jats:italic>\u00a0=\u00a04.38\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>). Our results implied that rs9266150 might not only play an important role in the development of psoriasis, but also be positively associated with the geographic location, gender and present skin lesion in the Chinese population.<\/jats:p>","DOI":"10.1111\/exd.13554","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T20:49:00Z","timestamp":1523306940000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of the novel susceptible locus rs9266150 with clinical features of psoriasis vulgaris in the Chinese Han population"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-6063","authenticated-orcid":false,"given":"Juan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"School of Life Sciences Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"School of Life Sciences Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"School of Life Sciences Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hequn","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Dermatology The First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.157"},{"key":"e_1_2_8_3_1","first-page":"1449","volume":"35","author":"Duffin K. C.","year":"2008","journal-title":"J. Rheumatol."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70188-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2340\/0001555577273276","volume":"77","author":"Enerback C.","year":"1997","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1618-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(02)00212-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2002.01458.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12569"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1342-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3576"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1273-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12595"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2827"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19612.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000038"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000606"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064683"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01398.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/342289"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.155044"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201308"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33415"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.07.014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds344"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.07.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1076"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.02.013"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195271"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.07.021"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091212-153455"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds226"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003103"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442203"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-009-0399-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091386"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.02.003"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100804"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1065-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.04.050"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91336-X"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.040"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01408.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1437-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.1.158"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.001"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T06:57:22Z","timestamp":1695452242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/exd.13554"],"URL":"https:\/\/doi.org\/10.1111\/exd.13554","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"2018-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}