{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:24:04Z","timestamp":1763141044286,"version":"3.37.3"},"reference-count":135,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 262"],"award-info":[{"award-number":["KFO 262"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) radiation has a plethora of effects on human tissues. In the <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> spectrum, wavelengths above 320\u00a0nm fall into the <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> range, and for these, it has been shown that they induce reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations and are capable to induce melanoma in mice. In addition to this, it was recently shown that <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> irradiation and <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> also increase glucose metabolism of melanoma cells. <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> irradiation causes a persistent increase in glucose consumption, accompanied by increased glycolysis, increased lactic acid production and activation of the pentose phosphate pathway. Furthermore, it was shown that the enhanced secretion of lactic acid is important for invasion of melanoma in vitro. The current knowledge of this link between <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>, metabolism and melanoma, possible mechanisms of <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010induced glucose metabolism and their starting points are discussed in this review with focus on <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010induced cellular stress signalling, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage signalling and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair systems. When looking at the benefits of <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\u2010induced glucose metabolism, it becomes apparent that there are more advantages of these metabolic changes than one would expect. Besides the role of lactic acid as initiator of protease expression and invasion, its role for immune escape of melanoma cells and the pentose phosphate pathway\u2010derived nicotinamide adenine dinucleotide phosphate (<jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>) as part of a <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> detoxification strategy are discussed.<\/jats:p>","DOI":"10.1111\/exd.13561","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:23:00Z","timestamp":1523838180000},"page":"941-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp>UVA<\/scp>, metabolism and melanoma: <scp>UVA<\/scp> makes melanoma hungry for metastasis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-8305","authenticated-orcid":false,"given":"York","family":"Kamenisch","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Drexler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Berneburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncs261"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(00)00006-3"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(02)00387-1"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12388"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051543"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.043"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.02.001"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.06.010"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06098.x"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00031.x"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.01.040"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950170711"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00033.x"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01025.x"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05142C"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp50413a"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.11.018"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14906"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401141101"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700458"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05185G"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13111"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000324107"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1454"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35095108"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09666"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1893"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114594"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1999.tb00090.x"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09299.x"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.10.008"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi220"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13010142"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.8.6.519"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3215.269"},{"key":"e_1_2_16_39_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9258(18)84849-9","volume":"65","author":"Cori C. F.","year":"1925","journal-title":"J. Biol. Chem."},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.282046"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12519287"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2001)0730432UEAUAC2.0.CO2"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.02.815"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911316106"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2010.03.004"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111721"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00815.x"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40087"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.365"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2013.08.019"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2015.09.004"},{"key":"e_1_2_16_52_1","first-page":"609","volume":"2011","author":"Rezvani H. R.","year":"1807","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051748"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414028111"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059006"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.10.001"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/ges071"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.22.15345"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4670"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.070490"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371798"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371736"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22502.x"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091834"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0930"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.131"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175549"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701074"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.327"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.2741\/1755"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.6"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-203"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.036"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.06.005"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110245200"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.330"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.05.013"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks066"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0286-6"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09918-3"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0555-x"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01825"},{"key":"e_1_2_16_83_1","first-page":"3278","volume":"55","author":"Board M.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2904"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206159"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00240-8"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20281"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1756509"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.11.010"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4977"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3633"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5517"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05265A"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2016.0310"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.021"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.10.005"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611397200"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-13-36"},{"key":"e_1_2_16_99_1","first-page":"1541","volume":"60","author":"Zhong H.","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2003.09.017"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2629"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105779"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130560"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121886"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506223200"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4369"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.965"},{"key":"e_1_2_16_108_1","first-page":"2257","volume":"20","author":"Haq R.","year":"2014","journal-title":"Can. Res."},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0440"},{"key":"e_1_2_16_110_1","first-page":"756","volume":"63","author":"Satyamoorthy K.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035972"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.011"},{"key":"e_1_2_16_113_1","first-page":"453","volume":"39","author":"Goetze K.","year":"2011","journal-title":"Int. J. Oncol."},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1795"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311939110"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13490"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24260"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2034"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066987"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9064-0"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0677-8"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-012-0080-x"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060868"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.04.009"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00141.x"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211485"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.05.006"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4634"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03486.x"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022498714522"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2010.01473.x"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.06.005"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.05.016"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508779113"},{"key":"e_1_2_16_135_1","first-page":"4242","volume":"57","author":"Boros L. G.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00924-2"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:49:02Z","timestamp":1694983742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":135,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/exd.13561"],"URL":"https:\/\/doi.org\/10.1111\/exd.13561","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"2018-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}