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Gene expression data from common inflammatory skin diseases (eg psoriasis, atopic dermatitis, seborrhoeic dermatitis and acne) and a novel statistical algorithm were used to define a unifying molecular signature referred to as the \u201cunhealthy skin signature\u201d (USS). Using a pattern\u2010matching algorithm, analysis of public data repositories revealed that the USS is found in diverse epithelial diseases. Studies of milder disruptions of epidermal homeostasis have also shown that these conditions converge, to varying degrees, on the USS and that the degree of convergence is related directly to the severity of homeostatic disruption. The USS contains genes that had no prior published association with skin, but that play important roles in many different disease processes, supporting the importance of the USS to homeostasis. Finally, we show through pattern matching that the USS can be used to discover new potential dermatologic therapeutics. The USS provides a new means to further interrogate epithelial homeostasis and potentially develop novel therapeutics with efficacy across a spectrum of skin conditions.<\/jats:p>","DOI":"10.1111\/exd.13694","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T17:59:56Z","timestamp":1527530396000},"page":"1000-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of gene expression profiles of multiple skin diseases identifies a conserved signature of disrupted homeostasis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-4973","authenticated-orcid":false,"given":"Kevin J.","family":"Mills","sequence":"first","affiliation":[{"name":"The Procter and Gamble Company Mason Business Center  Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Robinson","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Mason Business Center  Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Sherrill","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Mason Business Center  Mason OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Schnell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Calico, LLC  South San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"H. 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