{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:14:09Z","timestamp":1792030449731,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL\u201037 plays an important role. However, involvement of the inflammatory cytokine IL\u201033 has not yet been studied. We explored the role played by IL\u201033 in the pathophysiology of rosacea. First, we immunohistochemically evaluated the expression of IL\u201033 and its receptor (ST2) in rosacea skin. Second, we exposed HaCaT cells to ultraviolet B (UVB) irradiation in the presence or absence of LL\u201037 and measured the expression of proinflammatory cytokines including IL\u201033. We also analysed VEGF (vascular endothelial growth factor) mRNA expression and protein release after costimulation of HaCaT cells by LL\u201037 and IL\u201033. Immunohistochemically, IL\u201033 expression was enhanced in the skin of rosacea patients, especially with erythematotelangiectatic subtype. In vitro, UVB and LL\u201037 synergistically increased mRNAs expression of proinflammatory cytokines, especially IL\u201033 and IL\u20101\u03b2. IL\u201033 protein release was also synergistically increased by LL\u201037 and UVB treatment. LL\u201037 and IL\u201033 stimulated VEGF mRNA expression and VEGF release from HaCaT cells. Our findings suggest that rosacea skin with abundant LL\u201037 may robustly produce and release IL\u201033 when exposed to UV radiation. IL\u201033 may participate in the angiogenesis and vasodilation of rosacea skin by enhancing VEGF release.<\/jats:p>","DOI":"10.1111\/exd.13702","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T15:11:12Z","timestamp":1528297872000},"page":"1023-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Increased expression of IL\u201033 in rosacea skin and UVB\u2010irradiated and LL\u201037\u2010treated HaCaT cells"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-9648","authenticated-orcid":false,"given":"Eunah","family":"Suhng","sequence":"first","affiliation":[{"name":"Yonsei Gowoon Dermatologic Clinic  Seoul Korea"},{"name":"Department of Dermatology Ewha Womans University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute for Integrative Regenerative Biomedical Engineering Dongguk University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ewha Womans University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ewha Womans University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Cho","sequence":"additional","affiliation":[{"name":"Research Institute for Integrative Regenerative Biomedical Engineering Dongguk University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ewha Womans University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30142"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08196.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17545"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2692"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.10.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01182.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12670"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13679"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12464"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13716"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.09.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.446"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.09.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2274"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.222"},{"key":"e_1_2_8_23_1","first-page":"20","volume":"7","author":"Two A. 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