{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:32:00Z","timestamp":1790605920511,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006596","name":"Consiliul National pentru Dezvoltare si Inovare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>New biomaterials based on nanoparticles (NP<\/jats:styled-content>s) carrying polyphenols\u2010rich extracts (Cornus mas)<\/jats:italic> recently showed promising anti\u2010inflammatory activity in psoriasis. We aimed to understand how topically delivered silver and gold nanoparticles complexed with Cornus mas<\/jats:italic> (Ag\u2010NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content>, Au\u2010NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content>) modulate inflammation in psoriasis at cellular and molecular level. The impact on psoriatic inflammation was assessed in vitro on pro\u2010inflammatory macrophages, by clinical score, high\u2010frequency ultrasonography and immunohistology of psoriasis plaques treated with Ag\u2010NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content>, Au\u2010NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content> or control. Incubation of pro\u2010inflammatory macrophages with nanoparticles significantly decreased the release of NO<\/jats:styled-content>, IL<\/jats:styled-content>\u201012 and TNF<\/jats:styled-content>\u2010\u03b1. Immunofluorescence confirmed that nanoparticles significantly reduced CD<\/jats:styled-content>68\u2010positive macrophages and their IL<\/jats:styled-content>\u201012 and TNF<\/jats:styled-content>\u2010\u03b1 production in human psoriasis plaques. NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content> appear to repress NF<\/jats:styled-content>\u2010\u03baB activation in macrophages, inhibiting the production of pro\u2010inflammatory factors with causal role in psoriasis. Ag and Au NP<\/jats:styled-content>s\u2010CM<\/jats:styled-content> represent a novel nanoparticle\u2010based \u201cgreen\u201d technology which may provide an efficient tool for modern psoriasis therapy, circumventing immunosuppression\u2010related side effects of biologicals.<\/jats:p>","DOI":"10.1111\/exd.13707","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T19:11:41Z","timestamp":1529089901000},"page":"1166-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Topical silver and gold nanoparticles complexed with Cornus mas<\/i> suppress inflammation in human psoriasis plaques by inhibiting NF<\/scp>\u2010\u03baB activity"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-5454","authenticated-orcid":false,"given":"Diana","family":"Crisan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergic Diseases University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Scharffetter\u2010Kochanek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Crisan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schatz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Hainzl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Olenic","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergic Diseases and Dermatologic surgery Helios Clinic Rottweil Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Sindrilaru","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergic Diseases University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.43"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.08.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201303947"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20476f"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"16","article-title":"International Journal of Latest Research","volume":"4","author":"Olenic L.","year":"2015","journal-title":"Sci. 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