{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:44:00Z","timestamp":1790682240034,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["26\u22126"],"award-info":[{"award-number":["26\u22126"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scleroderma or systemic sclerosis (SSc) is a clinically heterogeneous rheumatological autoimmune disease affecting the skin, internal organs and blood vessels. There is at present no effective treatment for this condition. Our study investigated the effects of 5\u2010aminolevulinic acid (5\u2010ALA), which is a precursor of haem synthesis, on graft\u2010vs\u2010host disease (GvHD)\u2010induced SSc murine model. Lymphocytes were intravenously injected from donor mice (B10.D2) into recipient BALB\/c mice (recombination\u2010activating gene 2 (Rag\u20102)\u2010null mice) deficient in mature T and B cells to induce sclerodermatous GvHD (scl\u2010GvHD). To investigate the effect of 5\u2010ALA on scl\u2010GvHD, combination of 5\u2010ALA and sodium ferrous citrate (SFC) was orally administered to the recipient mice for 9\u00a0weeks. 5\u2010ALA\/SFC treatment significantly reduced progressive inflammation and fibrosis in the skin and ears. Furthermore, 5\u2010ALA\/SFC suppressed mRNA expression of transforming growth factor\u2010\u03b2, type I collagen and inflammatory cytokines. These results indicate that the 5\u2010ALA\/SFC combination treatment has a protective effect against tissue fibrosis and inflammation in a murine scl\u2010GvHD\u2010induced skin and ear inflammation and fibrosis. Furthermore, the efficacy of 5\u2010ALA\/SFC suggests important implications of HO\u20101 protective activity in autoimmune diseases, and therefore, 5\u2010ALA\/SFC may have promising clinical applications. These findings suggested that the 5\u2010ALA\/SFC treatment may be the potential strategies for SSc.<\/jats:p>","DOI":"10.1111\/exd.13730","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T07:58:11Z","timestamp":1530863891000},"page":"1104-1111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Combination of 5\u2010aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"27","author":[{"given":"Chi","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Transplantation Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Transplantation Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Institute of Rheumatology, Immunology and Allergy Fudan University  Shanghai China"},{"name":"Department of Rheumatology Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Fujino","sequence":"additional","affiliation":[{"name":"Division of Transplantation Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"AIDS Research Center National Institute of Infectious Diseases  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ito","sequence":"additional","affiliation":[{"name":"SBI Pharmaceuticals Co., Ltd.  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