{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:06:36Z","timestamp":1773291996933,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["90715614"],"award-info":[{"award-number":["90715614"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human skin graft mouse models are widely used to investigate and develop therapeutic strategies for the severe generalized form of recessive dystrophic epidermolysis bullosa (RDEB), which is caused by biallelic null mutations in <jats:italic>COL7A1<\/jats:italic> and the complete absence of type VII collagen (C7). Most therapeutic approaches are focused on reintroducing C7. Therefore, C7 and anchoring fibrils are widely used as readouts in therapeutic research with skin graft models. In this study, we investigated the expression pattern of human and murine C7 in a grafting model, in which human skin is reconstituted out of in vitro cultured keratinocytes and fibroblasts. The model revealed that murine C7 was deposited in both human healthy control and RDEB skin grafts. Moreover, we found that murine C7 is able to form anchoring fibrils in human grafts. Therefore, we advocate the use of human\u2010specific antibodies when assessing the reintroduction of C7 using RDEB skin graft mouse models.<\/jats:p>","DOI":"10.1111\/exd.13744","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T16:08:42Z","timestamp":1531930122000},"page":"1153-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Murine type VII collagen distorts outcome in human skin graft mouse model for dystrophic epidermolysis bullosa"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-6386","authenticated-orcid":false,"given":"Jeroen","family":"Bremer","sequence":"first","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"},{"name":"Department of Genetics Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duco","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryll S.","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Gosty\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles F. H.","family":"Diercks","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"},{"name":"Department of Pathology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel F.","family":"Jonkman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"},{"name":"Department of Genetics Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M. G.","family":"Pasmooij","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center of Expertise of Blistering Diseases University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.13744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:34:40Z","timestamp":1694252080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/exd.13744"],"URL":"https:\/\/doi.org\/10.1111\/exd.13744","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"2018-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}