{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:33:50Z","timestamp":1787499230450,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573066"],"award-info":[{"award-number":["81573066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030313098"],"award-info":[{"award-number":["2014A030313098"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n This study investigated predictors of response to topical diphenylyclopropenone (\n DPCP<\/jats:styled-content>\n ) immunotherapy in patients with alopecia areata (\n AA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To identify predictors of response, or resistance, to treatment for\n AA<\/jats:styled-content>\n through clinical observations and serum tests.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty four\n AA<\/jats:styled-content>\n patients were treated with\n DPCP<\/jats:styled-content>\n . Serum cytokine levels were measured in 33\n AA<\/jats:styled-content>\n patients pre\u2010 and post\u2010treatment, and in 18 healthy controls, using\n ELISA<\/jats:styled-content>\n assays.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of patients, 56.1% responded to\n DPCP<\/jats:styled-content>\n with satisfactory hair regrowth; the response rate was negatively correlated with hair loss extent. Before\n DPCP<\/jats:styled-content>\n treatment, higher serum\n IFN<\/jats:styled-content>\n \u2010\u03b3 and\n IL<\/jats:styled-content>\n \u201012 cytokine levels were observed in\n AA<\/jats:styled-content>\n patients compared to healthy controls. Non\u2010responders to\n DPCP<\/jats:styled-content>\n had significantly elevated serum\n IL<\/jats:styled-content>\n \u20104 pre\u2010treatment (3.07 fold higher) and lower\n IL<\/jats:styled-content>\n \u201012 levels compared with responders. After\n DPCP<\/jats:styled-content>\n treatment, non\u2010responders had persistently high\n IL<\/jats:styled-content>\n \u20104, increased\n IL<\/jats:styled-content>\n \u201012, negligible decrease in\n IFN<\/jats:styled-content>\n \u2010\u03b3 and decreased\n IL<\/jats:styled-content>\n \u201010. Post\u2010treatment\n DPCP<\/jats:styled-content>\n responders exhibited significantly decreased\n IFN<\/jats:styled-content>\n \u2010\u03b3 and\n IL<\/jats:styled-content>\n \u201012, and increased\n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201010. Development of adverse side\u2010effects was significantly associated with higher pre\u2010treatment serum IgE levels.\n <\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n A small number of subjects were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Potentially, elevated pre\u2010treatment serum levels of\n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201012 can be used as unfavorable and favorable predictors of\n DPCP<\/jats:styled-content>\n therapeutic effect, respectively. In addition, pre\u2010treatment elevated serum total IgE may predict increased risk for severe adverse side\u2010effects to\n DPCP<\/jats:styled-content>\n application. Whether serum cytokine expression levels can be used as predictors of response to other forms of treatment is unknown, but it may warrant investigation in the development of personalized treatments for\n AA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/exd.13758","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T05:39:24Z","timestamp":1532583564000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Serum level of\n IL<\/scp>\n \u20104 predicts response to topical immunotherapy with diphenylcyclopropenone in alopecia areata"],"prefix":"10.1111","volume":"29","author":[{"given":"Yugang","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Institute of Dermatology and Venereology Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiling","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sillani","family":"Caulloo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-3832","authenticated-orcid":false,"given":"Kevin J.","family":"McElwee","sequence":"additional","affiliation":[{"name":"Centre for Skin Science University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01427.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00385.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12489"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131412"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12209"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb11842.x"},{"key":"e_1_2_8_8_1","first-page":"541","volume":"66","author":"Paus R.","year":"1993","journal-title":"Yale J. 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