{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:22:52Z","timestamp":1791940972331,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005107","name":"Australasian Blistering Diseases Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005107","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteopenia or osteoporosis is one of the many comorbidities in patients with Epidermolysis Bullosa (<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>). Current literature on the prevalence of osteoporosis in <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review will analyse the current literature in the field of patients with compromised bone health in <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> and any articles on the prevalence of such diseases in <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search for articles related to bone health and epidermolysis bullosa (<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>) (1946\u20102017) was performed on seven databases: <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EBM<\/jats:styled-content>, PubMed, ProQuest, Scopus and Web of Science. Search terms: epidermolysis bullosa, osteop*, bone mass, bone mineral*, fracture, dual X\u2010ray absorptiometry, vitamin D, calcium, nutrition, exercise and physical activity. Abstracts from all search results were screened, and reference scanning of the search results was performed. Eighty\u2010three articles met the selection criteria and were considered for review. Letters to the editor and abstract\u2010only articles were excluded. Articles were favoured based on citation count, impact factor of their journal and study sample size. The search included all languages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The searches yielded a total of 1309 articles including 717 duplicates. The remaining 592 articles were screened by title and abstracts. Eighty\u2010three full\u2010text articles were analysed. Twenty\u2010one articles directly relating to bone health in <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> were included. Three descriptive studies and one case\u2010control study were found, indicating a need for research of larger scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further investigations into osteoporosis in <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>, especially the milder forms of <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>, are valuable in providing evidence to support guideline developments for <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> bone health management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.13771","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T14:10:43Z","timestamp":1534515043000},"page":"1122-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and pathogenesis of osteopenia and osteoporosis in epidermolysis bullosa: An evidence\u2010based review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-2764","authenticated-orcid":false,"given":"Jessica Szu\u2010Chia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology St George Hospital  Sydney NSW Australia"},{"name":"Faculty of Medicine University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-5484","authenticated-orcid":false,"given":"Anes","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology St George Hospital  Sydney NSW Australia"},{"name":"Faculty of Medicine University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-0199","authenticated-orcid":false,"given":"D\u00e9d\u00e9e F.","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology St George Hospital  Sydney NSW Australia"},{"name":"Faculty of Medicine University of New South Wales  Sydney NSW Australia"},{"name":"Faculty of Medicine University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00800.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_7_4_1","first-page":"1119","volume":"97","author":"Kim E. 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