{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:41:01Z","timestamp":1787499661687,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573041"],"award-info":[{"award-number":["81573041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17ZR1417400"],"award-info":[{"award-number":["17ZR1417400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>\n \n Human prolactin (\n PRL<\/jats:styled-content>\n ) is a well\u2010known hormone for pituitary of lactation and reproduction, but it also has immunostimulatory effect in some inflammatory or autoimmune diseases including psoriasis, which has not been well elucidated. This study aimed to determine the relationship between\n PRL<\/jats:styled-content>\n and psoriasis through clinical case\u2010control studies, and explore the function of\n PRL<\/jats:styled-content>\n in the pathogenesis of imiquimod (\n IMQ<\/jats:styled-content>\n )\u2010induced psoriasis\u2010like mouse model. Serum from patients with psoriasis vulgaris (PsV), patients with erythrodermic psoriasis, and healthy controls (\n HC<\/jats:styled-content>\n s) were collected for\n PRL<\/jats:styled-content>\n test. Skin biopsies were collected for\n PRL<\/jats:styled-content>\n ,\n PRL<\/jats:styled-content>\n receptors (\n PRLR<\/jats:styled-content>\n s), cytokines\n mRNA<\/jats:styled-content>\n level determination,\n PRL<\/jats:styled-content>\n immunohistochemistry and\n PRL<\/jats:styled-content>\n Western blotting. Mice were divided into four groups (each n\u00a0=\u00a06): control group (\n CON<\/jats:styled-content>\n ),\n IMQ<\/jats:styled-content>\n group, anti\u2010\n PRL<\/jats:styled-content>\n group and solvent group. Anti\u2010\n PRL<\/jats:styled-content>\n group and solvent group mice were treated with\n PRL<\/jats:styled-content>\n antagonist (cabergoline) and the solvent (0.25% methylcellulose) separately. The serum\n PRL<\/jats:styled-content>\n level of PsV patients was significantly higher than that of\n HC<\/jats:styled-content>\n s (\n P<\/jats:italic>\n \u00a0<\u00a00.001). Compared with\n HC<\/jats:styled-content>\n s, the\n mRNA<\/jats:styled-content>\n levels of\n PRL<\/jats:styled-content>\n and Th1\/Th17 cytokines in skin lesions increased significantly (\n P<\/jats:italic>\n \u00a0<\u00a00.05), and the\n PRL<\/jats:styled-content>\n protein level was also significantly elevated in the epidermis and dermis of PsV patients. In\n IMQ<\/jats:styled-content>\n \u2010induced psoriasis\u2010like mouse model, the\n mRNA<\/jats:styled-content>\n and protein levels of\n PRL<\/jats:styled-content>\n in skin lesions were significantly higher than\n CON<\/jats:styled-content>\n group (\n P<\/jats:italic>\n \u00a0<\u00a00.01). Comparing to solvent group, serum\n PRL<\/jats:styled-content>\n level and\n PRL<\/jats:styled-content>\n , cytokines\n mRNA<\/jats:styled-content>\n levels in skin lesions all decreased significantly and the skin inflammatory condition was also alleviated obviously in anti\u2010\n PRL<\/jats:styled-content>\n group. This study suggests that local production of\n PRL<\/jats:styled-content>\n is the main resource of\n PRL<\/jats:styled-content>\n in skin lesions and may play an important role in skin inflammatory of psoriasis.\n <\/jats:p>","DOI":"10.1111\/exd.13772","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T04:45:45Z","timestamp":1534567545000},"page":"1245-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Local production of prolactin in lesions may play a pathogenic role in psoriatic patients and imiquimod\u2010induced psoriasis\u2010like mouse model"],"prefix":"10.1111","volume":"27","author":[{"given":"Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatoimmunology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunli","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiru","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-6427","authenticated-orcid":false,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05552.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102834"},{"key":"e_1_2_8_4_1","first-page":"CD001976","author":"Owen C. 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