{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:18:27Z","timestamp":1782782307788,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences","award":["95-02-101-32315"],"award-info":[{"award-number":["95-02-101-32315"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently,<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18 polymorphism has played a role in increasing the risk of pemphigus among some populations such as Egyptian and Jewish. In addition, a variant within the<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18 promoter gene was shown to induce<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18 upregulation and cytokine secretion leading to keratinocyte susceptibility to anti\u2010desmoglein antibodies. Thus, the present study aimed to assess the<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18 single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) relationship with pemphigus, disease severity and family history among Iranian population. A total of 111 pemphigus patients and 201 healthy controls were genotyped for three<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s rs2304365, rs10504140 and rs4074067 by using<jats:styled-content style=\"fixed-case\">TETRA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARMS PCR<\/jats:styled-content>method. The results indicated that risk allele A in rs2304365 was significantly higher in pemphigus patients, compared with the amount in the control group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.43<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.49\u20103.975,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Thus, A allele represents a risk factor for pemphigus. Further, the patients carrying the risk allele had a more severe disease and a higher age of disease onset while no relationship was observed between the number of relapses and positive family history of pemphigus with the risk allele. Finally, dominant model was regarded as the strongest inheritance model for the associated risk. The present study confirmed the relationship between<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>18 gene with pemphigus disease, a more severe disease, and a higher age of disease onset.<\/jats:p>","DOI":"10.1111\/exd.13778","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:48:26Z","timestamp":1536335306000},"page":"1395-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The association between<scp>ST<\/scp>18 gene polymorphism and severe pemphigus disease among Iranian population"],"prefix":"10.1111","volume":"27","author":[{"given":"Ifa","family":"Etesami","sequence":"first","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Seirafi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Ghandi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzeh","family":"Salmani","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Arabpour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nasrollahzadeh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Teimourpour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-4209","authenticated-orcid":false,"given":"Mohammad","family":"Keramatipour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13488"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.606444"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00603"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8662-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600971497"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9244-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.09.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.11.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.46"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-111013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"456841","DOI":"10.1155\/2010\/456841","author":"Bektas M.","year":"2010","journal-title":"Dermatol. 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