{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:25:07Z","timestamp":1792171507107,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K10143"],"award-info":[{"award-number":["16K10143"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Minocycline\/tetracycline is clinically used for the treatment of bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), and its clinical benefits are superior to those of prednisolone when considering adverse events. Although the clinical benefits of minocycline\/tetracycline are well known, its immunosuppressive mechanisms are still unclear. In this study, we investigated the immunomodulatory effects of traditional anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> drugs (minocycline, nicotinic acid amide, dexamethasone and cyclosporine) on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> M2 macrophages in vitro, with special focus on the production of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>18 and <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>22, both of which are produced by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> M2 macrophages in the lesional skin of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and are increased in the serum of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients. Minocycline decreased the production of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>22, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>24 and <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>26 as well as <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 from M2 macrophages. <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>18 from M2 macrophages was decreased by dexamethasone and cyclosporine, but not decreased by minocycline. These data suggest that the clinical benefit of minocycline is partially explained by its suppressive effects against the production of specific Th2 chemokines from M2 macrophages, which should contribute to the recruitment of Th2 cells and eosinophils in the lesional skin of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/exd.13779","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:51:10Z","timestamp":1536335470000},"page":"1268-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Minocycline decreases Th2 chemokines from M2 macrophages: Possible mechanisms for the suppression of bullous pemphigoid by traditional bullous disease drugs"],"prefix":"10.1111","volume":"27","author":[{"given":"Kayo","family":"Tanita","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yota","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbing","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30560-3"},{"key":"e_1_2_9_3_1","first-page":"762","volume":"96","author":"Yasukochi A.","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1920"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12873"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365946"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.488"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12962"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.209"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl224"},{"key":"e_1_2_9_11_1","first-page":"212437","volume":"2015","author":"Zhang P.","year":"2015","journal-title":"Int. J. Anal. Chem."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07601.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13157"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.05.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08979.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1684\/ejd.2014.2283","volume":"24","author":"Fujimura T.","year":"2014","journal-title":"Eur. J. Dermatol."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13417"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27180"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.03.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01966.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04464.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxu079"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12566"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-014-0313-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14864"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Fexd.13779","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T00:10:01Z","timestamp":1694909401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/exd.13779"],"URL":"https:\/\/doi.org\/10.1111\/exd.13779","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"2018-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}