{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:42:56Z","timestamp":1785552176029,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Miami Miller School of Medicine SAC Award","award":["2017-39"],"award-info":[{"award-number":["2017-39"]}]},{"name":"Department of Dermatology & Cutaneous Surgery"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seborrhoeic Dermatitis (SD) is a common inflammatory skin disorder, but its molecular pathogenesis remains elusive. Previously, we have established the <jats:italic>Mpzl3<\/jats:italic> knockout (\u2212\/\u2212) mice as a model for SD. In this study, we focused on early phases of skin inflammation and determined the cytokine profiles and identified immune cell types in the lesional skin in the <jats:italic>Mpzl3<\/jats:italic> \u2212\/\u2212 mice. Using flow cytometry, we detected a significant increase of CD45+ leucocytes, CD3+ T lymphocytes and especially \u03b3\u03b4 T cells but not \u03b1\u03b2 T cells in the lesional skin compared to control. We also detected high levels of IL\u201017 and determined that the \u03b3\u03b4 T cells were a major contributing source. CD3+ and \u03b3\u03b4 T cell localization in the skin was verified by indirect immunofluorescent staining. Since neither \u03b3\u03b4 T cells nor IL\u201017 had been implicated in SD, our study provides novel insights into the role of MPZL3 in the pathogenesis of SD\u2010like skin inflammation.<\/jats:p>","DOI":"10.1111\/exd.13798","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T12:10:06Z","timestamp":1539259806000},"page":"1408-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Increased IL\u201017\u2010expressing \u03b3\u03b4 T cells in seborrhoeic dermatitis\u2010like lesions of the <i>Mpzl3<\/i> knockout mice"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-7986","authenticated-orcid":false,"given":"Tongyu C.","family":"Wikramanayake","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Hirt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"Almastadi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-0193","authenticated-orcid":false,"given":"Marjana","family":"Tomic\u2010Canic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-2433","authenticated-orcid":false,"given":"Natasa","family":"Strbo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"10","volume":"3","author":"Borda L.","year":"2015","journal-title":"J. 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