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However, the specific functional contributions of individual regions within this network remain poorly understood. We investigated whether contralateral primary and secondary somatosensory cortices (S1, S2) and ipsilateral inferior frontal gyrus (<jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>) are critically involved in the cortical processing of acute itch. Continuous theta burst transcranial magnetic stimulation (<jats:styled-content style=\"fixed-case\">cTBS<\/jats:styled-content>) was applied to either S1, S2 or <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>, followed by itch induction using a histamine prick. Results indicate a significant reduction in itch intensity when <jats:styled-content style=\"fixed-case\">cTBS<\/jats:styled-content> was applied to S1. Stimulation of S2 or the <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content> was not associated with a significant reduction in itch intensity. The novel finding of an antipruritic effect elicited by disruption of activity in contralateral S1 suggests a causal role of S1 in encoding the sensory\u2010discriminative aspect of itch and might be important in future studies on brain interventions for the treatment of itch.<\/jats:p>","DOI":"10.1111\/exd.13803","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T13:19:22Z","timestamp":1539695962000},"page":"1380-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transcranial magnetic stimulation over contralateral primary somatosensory cortex disrupts perception of itch intensity"],"prefix":"10.1111","volume":"28","author":[{"given":"Olivia","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Psychology University of Hull  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-8737","authenticated-orcid":false,"given":"Igor","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Hull  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-1053","authenticated-orcid":false,"given":"Henning","family":"Holle","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Hull  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.11.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31826b1329"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.07.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.033"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.10.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00193.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.6.3004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09308.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_8_13_1","first-page":"149","volume":"2","author":"Williams E. 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