{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:58:50Z","timestamp":1792598330930,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lichen planopilaris (<jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>) is a primary cicatricial alopecia characterized by the infiltration of lymphocytes in the upper portion of hair follicles. Inflammation around the bulge region of hair follicles induces destruction of hair follicle stem cells and tissue fibrosis, resulting in permanent hair loss. Treatment is still challenging, and the precise pathophysiology of this disorder is unknown. To clarify the pathogenesis of <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>, we performed histological and immunohistochemical analysis on specimens obtained from <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> patients. Formalin\u2010fixed and paraffin\u2010embedded samples were evaluated by staining with haematoxylin and eosin (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>), toluidine blue stain, immunohistochemistry and immunofluorescence. The immunohistochemical analysis demonstrated that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u2010positive T cells preferentially infiltrated into the follicular infundibulum in the <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> lesions. Toluidine blue stain detected a large number of mast cells in the inflammatory lesions of <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>. Interestingly, immunohistochemical analysis demonstrated that the mast cells harboured <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\u2010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023\u2010producing activity and expressed the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 receptor. The number of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\u2010positive mast cells was significantly higher in the <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> lesions than in normal scalp. Moreover, the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 receptor was expressed exclusively in the follicular epithelial cells in the <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> lesions. These results suggested that mast cells infiltrating hair follicles might play a role in the pathogenesis of <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> via the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 axis.<\/jats:p>","DOI":"10.1111\/exd.13816","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T13:44:54Z","timestamp":1540993494000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<scp>IL<\/scp>\u201017\u2010positive mast cell infiltration in the lesional skin of lichen planopilaris: Possible role of mast cells in inducing inflammation and dermal fibrosis in cicatricial alopecia"],"prefix":"10.1111","volume":"29","author":[{"given":"Ayako","family":"Hobo","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-4097","authenticated-orcid":false,"given":"Kazutoshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryokichi","family":"Irisawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.68"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"C.Bolduc L. 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