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Solute carrier family 2 member 1 (<jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>2A1), also named <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1, transports glucose and its analogues into cells. With elevated membrane\u2010bound <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1, psoriatic keratinocytes uptake more glucose with increased glucose metabolism. Competition between glucose and its analogues can serve as a strategy to inhibit glycolysis as well as proliferation. In this study, we investigated the expression patterns of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 in keratinocytes in the human psoriasis vulgaris and imiquimod\u2010induced psoriasis model, and determined that the glucose metabolism inhibitor 2\u2010deoxy\u2010D\u2010glucose (2\u2010<jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content>) can relieve the psoriatic lesions. We found membrane\u2010enriched <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 in psoriasis keratinocytes, which suggested some potential for glucose metabolic target therapy based on the glycolytic microenvironment. Furthermore, 2\u2010<jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content> was able to relieve the psoriatic lesions in an in vivo animal model which provides a new possible therapeutic strategy.<\/jats:p>","DOI":"10.1111\/exd.13850","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T14:00:31Z","timestamp":1543327231000},"page":"198-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Membrane\u2010enriched solute carrier family 2 member 1 (<scp>SLC<\/scp>2A1\/<scp>GLUT<\/scp>1) in psoriatic keratinocytes confers sensitivity to 2\u2010deoxy\u2010D\u2010glucose (2\u2010<scp>DG<\/scp>) treatment"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-0111","authenticated-orcid":false,"given":"Xiaoyan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis  Changsha Hunan China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7553-0880","authenticated-orcid":false,"given":"Junchen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis  Changsha Hunan China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-1726","authenticated-orcid":false,"given":"Weiqi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis  Changsha Hunan China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-9086","authenticated-orcid":false,"given":"Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Maternal and Child Health Care Hospital  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7677-107X","authenticated-orcid":false,"given":"Mingliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis  Changsha Hunan China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-636X","authenticated-orcid":false,"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis  Changsha Hunan China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"65","volume":"361","author":"Nestle F. 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