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It has been proposed that the major stimuli for wound closure are blood\u2010derived growth factors, chemokines and cytokines. The small <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content>ase R\u2010Ras, a known integrin activator, also regulates vascular permeability during angiogenesis, and blood vessels lacking R\u2010Ras leak plasma proteins constantly. We explored whether the access to blood\u2010derived proteins influences skin wound healing in R\u2010Ras knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) mice. In skin wounds, R\u2010Ras expression was mostly restricted to the vasculature in the granulation tissue. Angiogenic blood vessels in the R\u2010Ras <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> mice were significantly more permeable than in wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) controls. Although the distances between epidermal tongues, and the <jats:italic>panniculus carnosus<\/jats:italic> muscles, were significantly longer in R\u2010Ras <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> controls before the granulation tissue formation took place, there were no differences in the wound closure or re\u2010epithelialization rates or granulation tissue formation. These findings were also corroborated in a special splint excision wound model. Our study shows that although R\u2010Ras does not influence the skin wound healing itself, the blood vessels lacking R\u2010Ras are leaky and thus could facilitate the access of blood\u2010derived proteins to the wound.<\/jats:p>","DOI":"10.1111\/exd.13851","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:34:24Z","timestamp":1543502064000},"page":"202-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["R\u2010Ras regulates vascular permeability, but not overall healing in skin wounds"],"prefix":"10.1111","volume":"28","author":[{"given":"Tuomo","family":"Ketom\u00e4ki","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"V\u00e4h\u00e4tupa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"May","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toini","family":"Pemmari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Ruikka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Hietamo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkka","family":"Kaipiainen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlan","family":"Barker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Parkkila","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"},{"name":"Fimlab laboratories Eye Centre &amp; Department of Orthopedics &amp; Traumatology Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannele","family":"Uusitalo\u2010J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"},{"name":"Fimlab laboratories Eye Centre &amp; Department of Orthopedics &amp; Traumatology Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-1759","authenticated-orcid":false,"given":"Tero A. 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