{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:43Z","timestamp":1790507803725,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\n \n A relationship between acne and free fatty acids (\n FFA<\/jats:styled-content>\n s) has been suggested recently. However, the effects of\n FFA<\/jats:styled-content>\n s on sebaceous glands are still largely unknown. At the same time, the role of\n FFA<\/jats:styled-content>\n s during chronic inflammation is well established. Considering that\n FFA<\/jats:styled-content>\n s are also a major component of sebum, it is likely that changes in\n FFA<\/jats:styled-content>\n affect both the synthesis of sebum and the inflammatory response in sebaceous glands. In this study, we examined a hypothesis that\n FFA<\/jats:styled-content>\n s increase the production of sebum and induce inflammation in the sebaceous glands. We found that treatment of\n SZ<\/jats:styled-content>\n 95 sebocytes with exogenously applied palmitic acid (\n PA<\/jats:styled-content>\n ), a major saturated\n FFA<\/jats:styled-content>\n , induced a significant increase in intracellular lipid levels. Moreover,\n PA<\/jats:styled-content>\n treatment also increased the expression and secretion of the proinflammatory cytokines in\n SZ<\/jats:styled-content>\n 95 sebocytes. We also found that Toll\u2010like receptors were required for the inflammatory response triggered by\n PA<\/jats:styled-content>\n . The results of our study strengthen the notion about the link between acne and\n FFA<\/jats:styled-content>\n s and suggest the mechanism underlying this relationship. Our results serve as a foundation for future work that will explore the association between\n FFA<\/jats:styled-content>\n and acne and pave way to the development of novel treatment options for acne.\n <\/jats:p>","DOI":"10.1111\/exd.13855","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T06:44:22Z","timestamp":1543733062000},"page":"207-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Enhancement of lipid content and inflammatory cytokine secretion in\n SZ<\/scp>\n 95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8819","authenticated-orcid":false,"given":"Chong Won","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-0498","authenticated-orcid":false,"given":"Yejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Brandenburg Medical School Theodor Fontane Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-6392","authenticated-orcid":false,"given":"Jin Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.08.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S69135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203755"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/530429"},{"key":"e_1_2_8_7_1","first-page":"S24","article-title":"Polyunsaturated fatty acids upregulate lipid synthesis and inflammatory signalling in SZ95 sebocytes by inducing the expression of the fatty acid synthesis enzymes SCD and FADS2","volume":"129","author":"Angres S.","year":"2009","journal-title":"J Invest 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Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T06:14:38Z","timestamp":1694672078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,29]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/exd.13855"],"URL":"https:\/\/doi.org\/10.1111\/exd.13855","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,29]]},"assertion":[{"value":"2018-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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