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Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non\u2010exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches.<\/jats:p>","DOI":"10.1111\/exd.13868","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T15:38:31Z","timestamp":1545665911000},"page":"667-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Involvement of non\u2010melanocytic skin cells in vitiligo"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-354X","authenticated-orcid":false,"given":"Emanuela","family":"Bastonini","sequence":"first","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-5500","authenticated-orcid":false,"given":"Barbara","family":"Bellei","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-5361","authenticated-orcid":false,"given":"Angela","family":"Filoni","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-0549","authenticated-orcid":false,"given":"Daniela","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Iacovelli","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-6639","authenticated-orcid":false,"given":"Mauro","family":"Picardo","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.3.279"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12500086"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1983.tb00328.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1992.tb03211.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1538"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23667.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22461"},{"key":"e_1_2_7_10_1","first-page":"12","volume":"21","author":"Aly D. 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