{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:41:32Z","timestamp":1772232092142,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Ministry of Health, Labour, and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Stratified epithelia have caught much attention as potential contributors to the development of dermal and oesophageal fibrosis in systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c). Galectin\u20107 is a marker of all types of stratified epithelia, which is involved in the maintenance of epidermal homeostasis. So far, the role of galectin\u20107 has not been studied in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the potential contribution of galectin\u20107 to the development of clinical manifestations in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Galectin\u20107 expression was examined in skin samples and cultured keratinocytes by immunostaining and\/or quantitative reverse transcription <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Serum galectin\u20107 levels were determined by enzyme\u2010linked immunosorbent assay in 63 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and 20 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Galectin\u20107 expression was markedly decreased in the epidermis of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c lesional skin compared with that of healthy control skin. Serum galectin\u20107 levels were significantly lower in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients than in healthy controls and inversely correlated with skin score. In addition, <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with diffuse pigmentation and those with oesophageal dysfunction had significantly decreased serum galectin\u20107 levels as compared to those without each symptom. Importantly, endothelin\u20101 stimulation suppressed galectin\u20107 expression in normal human keratinocytes, and bosentan, a dual endothelin receptor antagonist, reversed circulating galectin\u20107 levels and epidermal galectin\u20107 expression in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Galectin\u20107 downregulation in stratified epithelia, which is mediated at least partially by autocrine endothelin stimulation, may contribute to the development of cutaneous manifestations and oesophageal dysfunction in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.13900","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T05:03:30Z","timestamp":1549775010000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A potential contribution of decreased galectin\u20107 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Ryosuke","family":"Saigusa","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine  Tokyo 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