{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:40:17Z","timestamp":1780324817919,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to evaluate whether variants in repair (<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>Asp312Asn,<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>Lys751Gln) and detoxification (<jats:italic><jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1<\/jats:italic>,<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>) genes alter risk, clinicopathological aspects and survival of cutaneous melanoma (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>). Genotyping was performed in 229<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>patients and 258 controls. Individuals with<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>312Asp\/Asn or Asn\/Asn plus<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>null genotype were under 2.00 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.06\u20103.79), and<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>312Asn\/Gln haplotype was under 1.44\u2010fold (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99\u20102.08) increased risks to<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>than others. Individuals with<jats:italic><jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1<\/jats:italic>plus<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>null genotype had 9.61\u2010fold (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.28\u201040.38) increased risk of metastatic<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>. At 60\u00a0months of follow\u2010up, patients with<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>751Gln\/Gln plus<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>null and<jats:italic><jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1<\/jats:italic>null plus<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>null genotype presented 7.36 and 3.05 more chances of evolving to death in multivariate Cox analysis, respectively. In conclusion, our data indicate, for the first time, that specific variant combinations of<jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic>,<jats:italic><jats:styled-content style=\"fixed-case\">GSTM<\/jats:styled-content>1<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">GSTT<\/jats:styled-content>1<\/jats:italic>may increase susceptibility to<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>and influence patients\u2019 clinicopathological features and survival.<\/jats:p>","DOI":"10.1111\/exd.13914","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T06:59:59Z","timestamp":1552978799000},"page":"631-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of functional variants Asp312Asn and Lys751Gln of<i>Xeroderma Pigmentosum Group D<\/i>(<i><scp>XPD<\/scp><\/i>) and<i>Glutathione S\u2010transferase Mu 1 (<scp>GSTM<\/scp>1)<\/i>and<i>Theta 1 (<scp>GSTT<\/scp>1)<\/i>genes on cutaneous melanoma susceptibility and prognosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Jos\u00e9 Augusto","family":"Rinck\u2010Junior","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences Department of Internal Medicine University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Torricelli","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Laboratory of Cancer Genetics University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Vilas B\u00f4as","family":"Gomez","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Laboratory of Cancer Genetics University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Laboratory of Cancer Genetics University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparecida Machado","family":"Moraes","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Department of Internal Medicine University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Jacob","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Laboratory of Cancer Genetics University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-2345","authenticated-orcid":false,"given":"Carmen Silvia Passos","family":"Lima","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Department of Internal Medicine University of Campinas Campinas S\u00e3o Paulo Brazil"},{"name":"Faculty of Medical Sciences Laboratory of Cancer Genetics University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05185G"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.04.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.6.463"},{"key":"e_1_2_10_6_1","first-page":"604","volume":"58","author":"Shen M. 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