{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:34:35Z","timestamp":1789846475039,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["PHRC 2011"],"award-info":[{"award-number":["PHRC 2011"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["NCT02157688"],"award-info":[{"award-number":["NCT02157688"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Folliculitis decalvans (FD) is a chronic inflammatory disease of unknown aetiology. Although <jats:italic>Staphylococcus aureus,<\/jats:italic> frequently found on lesional skin, is thought to play a causal role, the importance of its involvement remains controversial. To examine the role of <jats:italic>S\u00a0aureus<\/jats:italic>, we compared superficial and subepidermal microbiota in 20 FD patients who had <jats:italic>S\u00a0aureus<\/jats:italic> on lesional skin and in 20 healthy controls using culture techniques and genomic identification, before and after an anti\u2010staphylococcal treatment; we also screened for <jats:italic>S\u00a0aureus<\/jats:italic> virulence factors. When present on lesional skin, <jats:italic>S\u00a0aureus<\/jats:italic> colonized non\u2010lesional and subepidermal skin in 80% of cases. These data imply a break in the epidermal barrier integrity and that an abnormal non\u2010lesional skin microbiota persists in FD. <jats:italic>S\u00a0aureus<\/jats:italic> had no superantigenic toxin in 31% of cases and no toxin specificity. Clinical improvement obtained in most cases upon treatment was associated with the disappearance of <jats:italic>S\u00a0aureus<\/jats:italic> in all studied areas, with an incomplete restoration of normal microbiota and a significant increase in negative bacterial samples. This persistent unbalanced, subepidermal microbiota may act as a reservoir of abnormal flora and explain the chronicity of FD, suggesting new avenues of research to restore normal microbiota.<\/jats:p>","DOI":"10.1111\/exd.13916","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:20:07Z","timestamp":1553509207000},"page":"295-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Folliculitis decalvans is characterized by a persistent, abnormal subepidermal microbiota"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-8527","authenticated-orcid":false,"given":"Bruno","family":"Matard","sequence":"first","affiliation":[{"name":"Centre Sabouraud H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Luc","family":"Donay","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Resche\u2010Rigon","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, SBIM, H\u00f4pital Saint\u2010Louis APHP Paris France"},{"name":"ECSTRA Team INSERM U1153 Paris France"},{"name":"Universit\u00e9 Paris 7\u2010Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tristan","sequence":"additional","affiliation":[{"name":"CNR des Staphylocoques, Facult\u00e9 de M\u00e9decine Lyon Est INSERM U111 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Farhi","sequence":"additional","affiliation":[{"name":"Dermatology Office Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Mercier\u2010Delarue","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Cavelier\u2013Balloy","sequence":"additional","affiliation":[{"name":"Service D'anatomopathologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Assouly","sequence":"additional","affiliation":[{"name":"Centre Sabouraud H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Petit","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Saint Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Bagot","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Saint Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Reygagne","sequence":"additional","affiliation":[{"name":"Centre Sabouraud H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058203"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.075549.107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.644"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.01.013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328728"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04591.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2015.11.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12482"},{"key":"e_1_2_10_10_1","first-page":"113","volume":"73","author":"Lavigne JP","year":"2015","journal-title":"Ann. 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