{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:40:26Z","timestamp":1791646826767,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005897","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Pathologie Sexuellement Transmissible","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa\/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle, associated with considerable tissue remodelling. Although abnormal cytokine expression was detected both in perilesional and in uninvolved skin, up to now there is no model allowing a better understanding of the implicit inflammatory mechanisms in HS. The aim of this study was to investigate the inflammatory response in HS skin by mean of an ex vivo model culture. To that purpose, nine skin biopsy specimens from patients suffering from HS and controls were cultured up to 4\u00a0days. Microscopy imaging investigations showed variations of collagen I and III organization, and an increase in elastin fibres fragmentation in HS skin after 4\u00a0days of culture. The HS matrix structure remodelling was associated with high level of MMP\u20102 and MMP\u20109 in HS lesional skin. After 4\u00a0days of culture, the MMP expression in HS perilesional skin reached the level observed in HS lesional skin. Concomitantly, an increase in IL\u20101\u03b2 concentration was observed in all skin samples after 4\u00a0days of culture, although IL\u20101\u03b2 concentrations remained significantly higher in HS lesional skin as compared with control skin. Meanwhile, neither IL\u201017 concentrations nor the inflammasome components NLRP3 and caspase\u20101 varied. Thus, our HS skin model culture showed that MMP\u2010induced matrix alteration could participate in HS inflammation by releasing biological active peptides and inflammatory factors from the extracellular matrix (ECM), and open new opportunities to investigate the regulation of the inflammatory mechanism associated with HS.<\/jats:p>","DOI":"10.1111\/exd.13919","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T13:36:11Z","timestamp":1553348171000},"page":"593-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Matrix remodelling and MMP expression\/activation are associated with hidradenitis suppurativa skin inflammation"],"prefix":"10.1111","volume":"28","author":[{"given":"Julia","family":"Sanchez","sequence":"first","affiliation":[{"name":"Department of Dermatology Reims University Hospital, University of Champagne\u2010Ardenne Reims France"},{"name":"EA 7509 IRMAIC, UFR Medicine University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-2855","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Le Jan","sequence":"additional","affiliation":[{"name":"EA 7509 IRMAIC, UFR Medicine University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Muller","sequence":"additional","affiliation":[{"name":"EA 7509 IRMAIC, UFR Medicine University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Plastic, Esthetic and Reconstructive Surgery Reims University Hospital, University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Digestive surgery Reims University Hospital, University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Durlach","sequence":"additional","affiliation":[{"name":"Department of Histopathology Reims University Hospital, University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Dermatology Reims University Hospital, University of Champagne\u2010Ardenne Reims France"},{"name":"EA 7509 IRMAIC, UFR Medicine University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Reguiai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Reims University Hospital, University of Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Antonicelli","sequence":"additional","affiliation":[{"name":"EA 7509 IRMAIC, UFR Medicine University of Champagne\u2010Ardenne Reims France"},{"name":"Department of Biological Sciences, Immunology, UFR Odontology University of Reims Champagne\u2010Ardenne Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12966"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb06264.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12098"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12550"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.045"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14075"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14214"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.033"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr110"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13482"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"Latz E","journal-title":"Nat. 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