{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:12:36Z","timestamp":1791576756939,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21772131"],"award-info":[{"award-number":["21772131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872535"],"award-info":[{"award-number":["81872535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over\u2010keratinization of follicular keratinocytes and <jats:italic>Propionibacterium acnes<\/jats:italic> (<jats:italic>P\u00a0acnes<\/jats:italic>) overgrowth. Salicylic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>), a beta\u2010hydroxy acid, is frequently used in the treatment of acne. <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> has been found to decrease skin lipids and to possess anti\u2010inflammatory properties. However, few studies have elucidated the mechanisms and pathways involved in such treatment of acne. In this study, we initially investigated the anti\u2010acne properties of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> in human <jats:styled-content style=\"fixed-case\">SEB<\/jats:styled-content>\u20101 sebocytes. Treatment with <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> decreased sebocyte lipogenesis by downregulating the adenosine monophosphate\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>)\/sterol response element\u2010binding protein\u20101 (<jats:styled-content style=\"fixed-case\">SREBP<\/jats:styled-content>\u20101) pathway and reduced inflammation by suppressing the <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway in these cells. Salicylic acid also decreased the cell viability of <jats:styled-content style=\"fixed-case\">SEB<\/jats:styled-content>\u20101 by increasing apoptosis via the death signal receptor pathway. Subsequently, histopathological analysis of a rabbit ear acne model after application of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> for three weeks confirmed that <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> suppressed the levels of cytokines and major pathogenic proteins around acne lesions, which supports the mechanisms suggested by our in vitro experiments. These results initially clarified that therapeutic activities of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> in acne vulgaris treatment could be associated with the regulation of <jats:styled-content style=\"fixed-case\">SREBP<\/jats:styled-content>\u20101 pathway and <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway in human <jats:styled-content style=\"fixed-case\">SEB<\/jats:styled-content>\u20101 sebocytes.<\/jats:p>","DOI":"10.1111\/exd.13934","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:03:33Z","timestamp":1555031013000},"page":"786-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Salicylic acid treats acne vulgaris by suppressing <scp>AMPK<\/scp>\/<scp>SREBP<\/scp>1 pathway in sebocytes"],"prefix":"10.1111","volume":"28","author":[{"given":"Jin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-8882","authenticated-orcid":false,"given":"Gu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"},{"name":"State Key Laboratory of Biotherapy West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.03.030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.0285a.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.6.726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361607"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13692"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13296"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13042"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13397"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12971"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.4103\/0378-6323.38398","volume":"74","author":"Khunger N.","year":"2008","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34007.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00452.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S84765"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.6.955"},{"key":"e_1_2_9_19_1","first-page":"40","volume":"9","author":"Zeichner J. A.","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.11.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00911A"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.030"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC04968G"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201503063"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.132"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701155"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20978"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404297101"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700278"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150125"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215327"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21398"},{"key":"e_1_2_9_35_1","first-page":"933","volume":"129","author":"Beani J. C.","year":"2002","journal-title":"Ann. Dermatol. Venereol."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12050"},{"key":"e_1_2_9_37_1","first-page":"1","volume":"19","author":"Harper J. C.","year":"2003","journal-title":"Adv. Dermatol."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102180999"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700289"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33869"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.29"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.292"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.13934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T19:24:23Z","timestamp":1694373863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/exd.13934"],"URL":"https:\/\/doi.org\/10.1111\/exd.13934","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]},"assertion":[{"value":"2018-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}