{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:56Z","timestamp":1787014196601,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["IRG-77-003-32"],"award-info":[{"award-number":["IRG-77-003-32"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012529","name":"Washington State University Vancouver","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002224","name":"Melanoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melanoma is the deadliest form of skin cancer, partially due to its inherent resistance to therapy. Here, we test in live larvae the hypothesis that mature melanosomes contribute to resistance to chemotherapeutic drug, cisplatin, via drug sequestration. We also compare three melanosome biogenesis proteins\u2014microphthalmia\u2010associated transcription factor (Mitfa), vacuolar protein sorting 11 (Vps11) and oculocutaneous albinism 2 (Oca2) to determine their respective contributions to chemoresistance. Melanocytes in zebrafish larvae harbouring loss\u2010of\u2010function mutations in the\n                    <jats:italic>mitfa<\/jats:italic>\n                    ,\n                    <jats:italic>vps11<\/jats:italic>\n                    or\n                    <jats:italic>oca2<\/jats:italic>\n                    genes are more sensitive to cisplatin damage than wild\u2010type larvae. As a comparison, we examined sensory hair cells of the lateral line, which are sensitive to cisplatin. Hair cells in\n                    <jats:italic>oca2 and mitfa<\/jats:italic>\n                    mutants do not show increased cisplatin sensitivity when compared to wild\u2010type larvae, suggesting the increase in cisplatin sensitivity could be melanocyte specific. However, hair cells in\n                    <jats:italic>vps11<\/jats:italic>\n                    mutants are more sensitive to cisplatin than their wild\u2010type counterparts, suggesting that this mutation increases cisplatin susceptibility in multiple cell types. This is the first in vivo study to show an increase in chemotherapeutic drug sensitivity when melanosome maturation mutations are present. The proteins tested, especially Oca2, represent novel drug targets for increasing the efficiency of melanoma chemotherapy treatment.\n                  <\/jats:p>","DOI":"10.1111\/exd.13937","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T04:46:04Z","timestamp":1555044364000},"page":"795-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes"],"prefix":"10.1111","volume":"28","author":[{"given":"Kersten A.","family":"Peterson","sequence":"first","affiliation":[{"name":"School of Biological Sciences Washington State University Vancouver Vancouver Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Neuffer","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences Washington State University Vancouver Vancouver  Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda E.","family":"Bean","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences Washington State University Vancouver Vancouver  Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"New","sequence":"additional","affiliation":[{"name":"Mathematics Washington State University Vancouver Vancouver  Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B.","family":"Coffin","sequence":"additional","affiliation":[{"name":"Integrative Physiology and Neuroscience Washington State University Vancouver Vancouver  Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-027X","authenticated-orcid":false,"given":"Cynthia D.","family":"Cooper","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences Washington State 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