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C\u2010C motif chemokine ligand 5 (CCL5) and its receptor C\u2010C motif chemokine receptor 5 (CCR5) play important roles in the activation and recruitment of T cells. This study sought to explore the expression and biological functions of the CCL5\u2010CCR5 axis in OLP. We examined the expression of the CCL5\u2010CCR5 axis in the peripheral blood and oral tissue of healthy controls and patients with OLP using quantitative real\u2010time PCR, Simple Western assays, enzyme\u2010linked immunosorbent assay (ELISA) and immunohistochemistry. In addition, we investigated the effects of the CCL5\u2010CCR5 axis on the proliferation, apoptosis and migration of OLP T cells using Cell Counting Kit\u20108 (CCK8) assay, flow cytometry and transwell assay. We found that the expression of the CCL5\u2010CCR5 axis was significantly elevated both in the peripheral blood and oral tissue of patients with OLP compared with healthy controls. CCL5 not only promoted OLP T\u2010cell proliferation and migration but also inhibited OLP T\u2010cell apoptosis. Moreover, CCR5 inhibition suppressed OLP T\u2010cell proliferation and migration, whereas OLP T\u2010cell apoptosis was promoted. In conclusion, our data suggest that the CCL5\u2010CCR5 axis may be closely related to the inflammatory infiltration of T cells in OLP.<\/jats:p>","DOI":"10.1111\/exd.13946","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T13:49:45Z","timestamp":1555854585000},"page":"816-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Expression and biological functions of the CCL5\u2010CCR5 axis in oral lichen planus"],"prefix":"10.1111","volume":"28","author":[{"given":"Jing","family":"Shan","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Oral Medicine Affiliated Hospital of Stomatology, Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of 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