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Thus, therapeutic advanced strategies are emerging from regenerative medicine. It has recently emerged that adipose tissue secretome may be used as a cell\u2010free therapy in skin regeneration since paracrine functions of adipose\u2010derived stem cells alone are responsible for most of the therapeutic effect of stem cells in several animal disease models. In this study, we tested the effect of adipose tissue extracellular fraction (AT\u2010Ex) isolated from lipoaspirates on dermal and epidermal vitiligo cells in vitro. Using this experimental model, we demonstrated that molecules secreted by adipose tissue ameliorate the capability to counteract oxidative stress by a physiological stimulation of intracellular antioxidant enzymes and positively impact on cell proliferation. Due to the presence of Wnt\u2010secreted factors, <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\u2010Ex treatment promotes glycogen synthase kinase 3\u03b2 inactivation and consequently Wnt\/\u03b2\u2010catenin pathway activation. Collectively, our findings show that <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\u2010Ex could be useful as a natural approach to improve treatment of vitiligo.<\/jats:p>","DOI":"10.1111\/exd.13954","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T13:50:33Z","timestamp":1557323433000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-5500","authenticated-orcid":false,"given":"Barbara","family":"Bellei","sequence":"first","affiliation":[{"name":"Laboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research San Gallicano Dermatological Institute IRCCS Rome Italy"},{"name":"Department of Plastic and Reconstructive Surgery San 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