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Since interleukin\u20101 receptor\u2010associated kinase (<jats:styled-content style=\"fixed-case\">IRAK<\/jats:styled-content>\u20101)\/nuclear factor\u2010kappa B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010kappa B) pathway plays an essential role in the pathogenesis of autoimmune diseases, the aim of the present study was to explore the role of polymorphisms in three genes, named <jats:styled-content style=\"fixed-case\">IRAK<\/jats:styled-content>1 (rs3027898), <jats:styled-content style=\"fixed-case\">NFKBIA<\/jats:styled-content> (rs696) and <jats:styled-content style=\"fixed-case\">NFKB<\/jats:styled-content>1 (\u201094<jats:styled-content style=\"fixed-case\">ATTG<\/jats:styled-content> insertion\/deletion variant, \u2010 rs28362491), in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> susceptibility. Forty\u2010four unrelated patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> (23 males) were enrolled in the study. Additionally, 77 ethnic matching healthy volunteers (45 males) with no personal or family history of chronic autoimmune or infectious diseases were studied. Strong statistical significant difference was observed between <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients and controls for polymorphism \u201094 insertion\/deletion <jats:styled-content style=\"fixed-case\">ATTG<\/jats:styled-content> in the promoter region of <jats:styled-content style=\"fixed-case\">NFKB<\/jats:styled-content>1 gene (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00005). Additional dedicated studies in larger groups of patients of various ethnicities are needed to replicate and confirm the preliminary findings.<\/jats:p>","DOI":"10.1111\/exd.13957","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T14:04:48Z","timestamp":1557583488000},"page":"972-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of <scp>NFKB<\/scp>1 \u201094<scp>ATTG<\/scp> ins\/del polymorphism (rs28362491) with pemphigus vulgaris"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-4222","authenticated-orcid":false,"given":"Anthoula","family":"Chatzikyriakidou","sequence":"first","affiliation":[{"name":"Laboratory of Medical Biology\u2014Genetics, Medical School Aristotle University Thessaloniki Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Kyriakou","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Papageorgiou General Hospital Medical School, Aristotle University Thessaloniki Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parthena","family":"Meltzanidou","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Papageorgiou General Hospital Medical School, Aristotle University Thessaloniki Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-222X","authenticated-orcid":false,"given":"Alexandros","family":"Lambropoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Biology\u2014Genetics, Medical School Aristotle University Thessaloniki Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology Papageorgiou General Hospital Medical School, Aristotle University Thessaloniki Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.04.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044313"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00053-4"},{"key":"e_1_2_8_6_1","first-page":"re3","author":"Dunne A.","year":"2003","journal-title":"Sci STKE"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1228704"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02381.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.05.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0607-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.6776"},{"key":"e_1_2_8_13_1","first-page":"1387","volume":"22","author":"Sun X. 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