{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:27:22Z","timestamp":1791228442914,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> is not clear, mechanical stress exacerbates <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. In this study, we aimed to determine whether intracellular adhesive junctions may be aberrant in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patient skin. Strikingly, we observed loss of E\u2010cadherin and p120ctn protein expression, two key adherens junction proteins, in ~85% of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> severe skin lesions. Moreover, loss of protein expression was apparent in non\u2010lesional skin from <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> patients and the degree of loss positively correlated with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> Hurley Stage of disease. E\u2010cadherin expression was unaltered in other inflammatory skin conditions including chronic wound epithelium, atopic dermatitis, and acne vulgaris compared with healthy skin suggesting that its loss may be uniquely relevant to <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> pathogenesis. A complete loss of \u03b1\u2010catenin, \u03b2\u2010catenin and <jats:styled-content style=\"fixed-case\">ZO<\/jats:styled-content>\u20101 was not observed; however, some cytoplasmic staining of the catenins was noted in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> epithelium. We also demonstrated diminished desmosome size in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> lesional skin. Overall, our data suggested that loss of adherens junction proteins and diminished desmosome size in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> skin contributes to the skin's inability to withstand mechanical stress and provides rationale as to why mechanical stress exacerbates <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> symptoms.<\/jats:p>","DOI":"10.1111\/exd.13973","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T17:48:05Z","timestamp":1558374485000},"page":"867-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["E\u2010cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8706","authenticated-orcid":false,"given":"Amanda M.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-2912","authenticated-orcid":false,"given":"Zhaoyuan","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-8670","authenticated-orcid":false,"given":"Samantha L.","family":"Gettle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-2789","authenticated-orcid":false,"given":"Amy L.","family":"Longenecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-5974","authenticated-orcid":false,"given":"Michal","family":"Kidacki","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine MD\/PhD Program Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-3796","authenticated-orcid":false,"given":"Joslyn S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Dermatology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-6582","authenticated-orcid":false,"given":"Douglas B.","family":"Stairs","sequence":"additional","affiliation":[{"name":"Department of Pathology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Danby","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth Hanover New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12233"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_9_4_1","first-page":"7250","volume":"58","author":"Janse I. 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