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There is no cure for any of the subtypes of EB resulting from different mutations, and current therapy only focuses on the management of wounds and pain. Novel effective therapeutic approaches are therefore urgently required. Strategies include gene\u2010, protein\u2010 and cell\u2010based therapies. This review discusses molecular procedures currently under investigation at the EB House Austria, a designated Centre of Expertise implemented in the European Reference Network for Rare and Undiagnosed Skin Diseases. Current clinical research activities at the EB House Austria include newly developed candidate substances that have emerged out of our translational research initiatives as well as already commercially available medications that are applied in off\u2010licensed indications. Squamous cell carcinoma is the major cause of death in severe forms of EB. We are evaluating immunotherapy using an anti\u2010PD1 monoclonal antibody as a palliative treatment option for locally advanced or metastatic squamous cell carcinoma of the skin unresponsive to previous systemic therapy. In addition, we are evaluating topical calcipotriol and topical diacerein as potential agents to improve the healing of skin wounds in EBS patients. Finally, the review will highlight the recent advancements of gene therapy development for EB.<\/jats:p>","DOI":"10.1111\/exd.13979","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T11:29:35Z","timestamp":1559129375000},"page":"1176-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Epidermolysis bullosa: Advances in research and treatment"],"prefix":"10.1111","volume":"28","author":[{"given":"Christine","family":"Prodinger","sequence":"first","affiliation":[{"name":"EB House Austria Research Program for Molecular Therapy of Genodermatoses Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4358-7011","authenticated-orcid":false,"given":"Julia","family":"Reichelt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann W.","family":"Bauer","sequence":"additional","affiliation":[{"name":"EB House Austria Research Program for Molecular Therapy of Genodermatoses Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Laimer","sequence":"additional","affiliation":[{"name":"EB House Austria Research Program for Molecular Therapy of Genodermatoses Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Department of Dermatology University Hospital of the Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-79271-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.127"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.11.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.01.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3701"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.11.003"},{"key":"e_1_2_8_11_1","author":"Vahidnezhad H.","year":"2018","journal-title":"Matrix Biol."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/302116"},{"key":"e_1_2_8_13_1","first-page":"S91","volume":"132","author":"Di Salvio M.","year":"2012","journal-title":"J. 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