{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:46:01Z","timestamp":1790847961237,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Palladium (Pd) is a common metal found in jewellery and dental appliances, but it has been shown to be likely to cause metal allergy. We previously reported that platinum (nPt) and palladium (nPd) nanoparticle\u2010containing mixture (PAPLAL) has both superoxide dismutase and catalase activities and that the topical application of PAPLAL improved skin atrophy induced by chronic oxidative damage in an ageing mouse model. However, the safety of PAPLAL for preventing Pd allergy remains unclear. In the present study, we investigated whether or not PAPLAL induces Pd allergy. We found that PAPLAL treatment caused no skin inflammation, while nPd administration caused only slight skin inflammation compared to the palladium chloride\u2010induced severe reaction in an experimental metal allergy model. A gene expression analysis revealed that PAPLAL treatment significantly suppressed the expression of <jats:italic>Inf\u2010\u03b3<\/jats:italic>, <jats:italic>Il\u20101\u03b2<\/jats:italic> and <jats:italic>Tnf\u03b1<\/jats:italic> genes. Even in human clinical trials using patches containing metal nanoparticles, nPd and PAPLAL failed to induce significant skin inflammation. These results suggest that mixing with nPt in PAPLAL suppresses the inflammation response of nPd. PAPLAL can be expected to be applied to various skin treatments as a safe topical substance.<\/jats:p>","DOI":"10.1111\/exd.13996","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T13:04:45Z","timestamp":1561986285000},"page":"1025-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Platinum and palladium nanoparticle\u2010containing mixture, PAPLAL, does not induce palladium allergy"],"prefix":"10.1111","volume":"28","author":[{"given":"Shuichi","family":"Shibuya","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Japan Society for the Promotion of Science Tokyo Japan"},{"name":"Aging Stress Response Project Team National Center for Geriatrics and Gerontology Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Aging Stress Response Project Team National Center for Geriatrics and Gerontology Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Research and Clinical Center for Yusho and Dioxin Kyushu University Hospital Fukuoka Japan"},{"name":"Department of Dermatology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Ichihashi","sequence":"additional","affiliation":[{"name":"Anti\u2010Aging Medical Research Center, Graduate School of Life and Medical Sciences Doshisha University Kyoto Japan"},{"name":"Faculty of Pharmaceutical Science Kobe Gakuin University Kobe Japan"},{"name":"Arts Ginza Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3351-3342","authenticated-orcid":false,"given":"Takahiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Aging Stress Response Project Team National Center for Geriatrics and Gerontology Obu 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