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This agent has been shown to normalize abnormally activated T\u2010cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16\u00a0weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell\u2010mediated autoimmune mouse disease, alopecia areata.<\/jats:p>","DOI":"10.1111\/exd.14008","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T16:14:07Z","timestamp":1563552847000},"page":"1091-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["2\u2010deoxy D\u2010glucose treatment does not elicit a hair growth response in alopecia areata"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-5430","authenticated-orcid":false,"given":"John P.","family":"Sundberg","sequence":"first","affiliation":[{"name":"The Jackson Laboratory Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-406X","authenticated-orcid":false,"given":"Kathleen 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