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New insights into the pathophysiology of itchy skin and potentially involved mediators have increased the interest in and development of new treatments that specifically act on targets involved in the transmission and perception of itching. Phototherapy has long been known and used as an effective treatment for various kinds of chronic itching. However, despite its well\u2010known beneficial effects, the mechanisms behind the antipruritic effect of phototherapy are less well\u2010known. In addition, phototherapy requires the use of expensive equipment in dermatology offices, patients must undergo repeated treatments and no large, randomized, controlled trials have yet supported the antipruritic effect of UV. Therefore, phototherapy is rarely recommended as a treatment method for chronic pruritic diseases or only used as a last recourse. However, the wide range of pruritic conditions that can be successfully treated with phototherapy, together with its low acute side effects, extremely low frequency of interactions with other medications, possibilities to combine phototherapy with other treatment modalities and the fact that patients of almost all ages\u2014from childhood to old age, including women during pregnancy or lactation\u2014can be treated make UV therapy advantageous over other treatments of chronic pruritus. Thus, despite the development of new targeted therapies against pruritus, UV therapy is neither outdated nor the \u2018last recourse\u2019, but should be considered early on in the treatment of chronic pruritus.<\/jats:p>","DOI":"10.1111\/exd.14011","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T09:53:44Z","timestamp":1564048424000},"page":"1432-1438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Is there still a role for UV therapy in itch treatment?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-4739","authenticated-orcid":false,"given":"Franz J.","family":"Legat","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00159.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12912"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(92)85080-E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","volume":"92","author":"Hanifin J. 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