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To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of <jats:italic>Rhizopus arrhizus<\/jats:italic> (<jats:italic>R.\u00a0arrhizus<\/jats:italic>) using wild\u2010type (WT) mice and Card9 knockout (<jats:italic>Card9<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) mice to investigate the antifungal effect of Card9 against <jats:italic>R.\u00a0arrhizus<\/jats:italic> infection. <jats:italic>Card9<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice were more susceptible to <jats:italic>R.\u00a0arrhizus<\/jats:italic> infection than WT mice, which could be related to the impaired NF\u2010\u03baB pathway activation, local cytokine production and Th cell responses in <jats:italic>Card9<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice.<\/jats:p>","DOI":"10.1111\/exd.14020","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T11:59:03Z","timestamp":1565697543000},"page":"1244-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by <i>Rhizopus arrhizus<\/i>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-1737","authenticated-orcid":false,"given":"Lingyue","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Peking University First Hospital Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing 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