{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:13:02Z","timestamp":1792383182455,"version":"4.4.0"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is increasing evidence that the intestinal microbiome plays an important role in modulating systemic inflammation and disease. Oral probiotics can modulate the intestinal microbiome and have demonstrated to be efficacious in treating topical skin conditions, such as atopic dermatitis, acne and rosacea. By proxy, exogenous application to the skin of probiotics should also promote a positive bacterial balance to mitigate or potentially eliminate pathologic conditions. The goal of this article was to provide a systematic review of studies that have investigated the role of topical probiotics in mitigating skin conditions. Additionally, skin conditions where dysbiosis has been identified but topical probiotics have not been investigated are discussed. We hope this review both analyses the evidence for the role that topical probiotics could play in topical skin conditions and highlights additional areas in need of research and exploration.<\/jats:p>","DOI":"10.1111\/exd.14032","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T14:13:55Z","timestamp":1567952035000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-4378","authenticated-orcid":false,"given":"Rebecca","family":"Knackstedt","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Knackstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology MetroHealth Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gatherwright","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery MetroHealth Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"560","volume":"9","author":"Quigley E. M.","year":"2013","journal-title":"Gastroenterol. Hepatol."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12489-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0135"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2017.03.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18846"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-7-r89"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.10.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129996"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182940cb8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000389"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14203"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25911"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120556"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2970"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2901-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1343664"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5145"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.10.015"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1365"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2015.0096"},{"key":"e_1_2_8_24_1","first-page":"5","volume":"99","author":"Petersen E. B. M.","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666181008113149"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12840"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.417"},{"key":"e_1_2_8_28_1","volume-title":"Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria","author":"FAO\/WHO","year":"2001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.022"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.044057-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12365"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307649"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2017.10.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0046"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000231"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.75"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.49.414"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028004210"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.02025.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105170200"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00307.2002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.538"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504001108747558"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00318-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.10.025"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2005.01.007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2062"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14052"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225152"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141067"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.182"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.138"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.12.569"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1086\/340126"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2010.00749.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00051.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00633.x"},{"key":"e_1_2_8_59_1","first-page":"380","volume":"16","author":"Di Marzio L.","year":"2006","journal-title":"Eur. J. Dermatol."},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200802100115"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-008-0179-y"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02508.x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00932.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2008.00577.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02793.x"},{"key":"e_1_2_8_66_1","first-page":"385","volume":"63","author":"Muizzuddin N.","year":"2012","journal-title":"J. Cosmet. Sci."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2024-6"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S135529"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4680"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3873-9"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475416685077"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903512156"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304110-00005"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12184"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00918.x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021481"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09892.x"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.008"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.02.006"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09095.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20204-8"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.432"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07481.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.131029.111"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb06447.x"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062211"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4673-4679.2004"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.002"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12655"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3010"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.05.127"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00836.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.42.100188.002301"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.012"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12550_6.x"},{"key":"e_1_2_8_96_1","first-page":"117","volume":"42","author":"Basal E.","year":"2004","journal-title":"J. Microbiol."},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_8_98_1","first-page":"1407","volume":"9","author":"Kircik L. H.","year":"2010","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.5.571"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2012.12026"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2007.0144"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081063"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14374"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.E029330"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041320"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12253"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-31"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002719"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-016-0038-z"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.7.4295"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124384"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01021"},{"key":"e_1_2_8_115_1","first-page":"1","volume":"28","author":"Zuuren E. J.","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000241"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.10.001"},{"key":"e_1_2_8_118_1","first-page":"21","volume":"9","author":"Lazaridou E.","year":"2011","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.054"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12355"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix604"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.14032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T03:55:37Z","timestamp":1694145337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/exd.14032"],"URL":"https:\/\/doi.org\/10.1111\/exd.14032","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"2019-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}