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Vitamin D has been mooted as a potential mediator. However, the evidence does not support this. I suggest that UV irradiation of the skin produces nascent malignant and premalignant cells with associated generic tumor\u2010specific antigens. These are eliminated by immunosurveillance resulting in adaptive immunity. The clonal expansion of these immune cells protects against tumors in other viscera, effectively immunising the host. The evidence for this \u201cheliovaccination\u201d is very strong. Childhood UV exposure protects against cancer in adulthood. Tumor na\u00efve individuals possess anti\u2010tumor antibodies. Antigen\u2010presenting cells mobilise to the skin following specifically UVB skin irradiation. It is time to rethink the link between UV light and cancer.<\/jats:p>","DOI":"10.1111\/exd.14087","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T13:28:04Z","timestamp":1582118884000},"page":"477-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heliovaccination: Solar mediated immunity against cancer"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-8679","authenticated-orcid":false,"given":"Chika Edward","family":"Uzoigwe","sequence":"first","affiliation":[{"name":"Harcourt House Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"volume-title":"The mortality from cancer throughout the world","year":"1915","author":"Hoffman F. L.","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","first-page":"191","volume":"1","author":"Apperly F. 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