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We examined the efficacy of CCR2 antagonist (RS\u2010504393) in a mouse model of scleroderma induced by bleomycin. RS\u2010504393 was administered via intradermal injection 6\u00a0hours prior to bleomycin injection, in the same sites. Histopathological examination showed that RS\u2010504393 treatment suppressed dermal fibrosis and decreased dermal thickness. The numbers of mast cells and myofibroblasts in the skin of RS\u2010504393\u2013treated mice were significantly lower compared with those in PBS\u2010treated mice. Moreover, the amount of collagen in the skin of RS\u2010504393\u2013treated mice was significantly lower compared with that in the PBS\u2010treated mice. Additionally, mRNA levels of TGF\u2010\u03b21 and collagen I alpha 1 in sclerotic skin were significantly decreased by RS\u2010504393, and semiquantitative histopathological scoring of the lungs showed inhibition of fibrosis in RS\u2010504393\u2013treated mice. The amount of collagen in the lung of the RS\u2010504393\u2013treated mice was lower compared with that in the PBS\u2010treated mice. These data suggest that CCR2 antagonist RS\u2010504393 may be a therapeutic agent for human scleroderma.<\/jats:p>","DOI":"10.1111\/exd.14088","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T07:11:07Z","timestamp":1582614667000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Antifibrogenic effects of C\u2010C chemokine receptor type 2 antagonist in a bleomycin\u2010induced scleroderma model"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-196X","authenticated-orcid":false,"given":"Masato","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"issue":"113","key":"e_1_2_9_2_1","first-page":"3","volume":"36","author":"Orlandi M.","year":"2018","journal-title":"Clin. 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