{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:35:17Z","timestamp":1788388517692,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne and rosacea, despite their similar clinical presentations, follow distinct clinical courses, suggesting that fundamental differences exist in their pathophysiology. We performed a case\u2010control study profiling the skin microbiota in rosacea and acne patients compared to matched controls. Nineteen rosacea and eight acne patients were matched to controls by age\u00a0\u00b1\u00a05\u00a0years, sex and race. DNA was extracted from facial skin swabs. The V3V4 region of the bacterial 16S rRNA gene was sequenced using Illumina MiSeq and analysed using QIIME\/Metastats 2.0 software. The mean relative abundance of <jats:italic>Cutibacterium acnes<\/jats:italic> in rosacea with inflammatory papules and pustules (20.454% \u00b116.943%) was more similar to that of acne (19.055% \u00b115.469%) than that of rosacea without inflammatory papules and pustules (30.419% \u00b121.862%). <jats:italic>C acnes<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.048) and <jats:italic>Serratia marcescens<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.038) were significantly enriched in individuals with rosacea compared to acne. Investigating the differences between the skin microbiota in acne and rosacea can provide important clues towards understanding the disease progression in each condition.<\/jats:p>","DOI":"10.1111\/exd.14098","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T21:03:38Z","timestamp":1586639018000},"page":"1375-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison of the skin microbiota in acne and rosacea"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3532-0779","authenticated-orcid":false,"given":"Katherine G.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Dermatology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M.","family":"Rainer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University Baltimore MD USA"},{"name":"Department of Dermatology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Florea","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel F.","family":"Mongodin","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences University of Maryland School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sewon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506630"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702493"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5221"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14437"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0558-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70065-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08028.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2014.04.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00471-5"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"39","volume":"94","author":"Olazagasti J.","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0168-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00210-17"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121045"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-2-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000352"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9993.1993.tb00438.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.075549.107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304040-00005"},{"key":"e_1_2_8_22_1","first-page":"19","volume":"18","author":"Lehrhoff S.","year":"2012","journal-title":"Dermatol. 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