{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:22:29Z","timestamp":1780662149699,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aetiology of vitiligo has not been fully elucidated, and several hypotheses have been investigated; among them, the most explored assumes an autoimmune basis for the disease. Supporting this hypothesis is the frequent co\u2010occurrence of autoimmune diseases with vitiligo. In addition, various genetic loci associated with vitiligo harbour key immune response genes. Our general hypothesis is that autoimmunity\u2010associated genes participate in the control of vitiligo susceptibility. To investigate this hypothesis, we tested for association between vitiligo and genes <jats:italic>CYP27B1<\/jats:italic>, <jats:italic>REL<\/jats:italic>, <jats:italic>TNFAIP3<\/jats:italic> and <jats:italic>IL2\/IL21<\/jats:italic>, all previously related to autoimmune diseases associated with vitiligo. The study was performed using two independent population samples: a family\u2010based discovery set (211 trios) and a replication set (131 cases\/119 controls). Statistically significant association with vitiligo was detected between markers of the <jats:italic>REL<\/jats:italic> and <jats:italic>IL2<\/jats:italic> gene in the family\u2010based sample. Both association signals were concentrated among patients displaying autoimmune comorbidity and non\u2010segmental vitiligo. Evidence for validation was detected for <jats:italic>IL2<\/jats:italic> marker. Our findings suggest <jats:italic>REL<\/jats:italic> and <jats:italic>IL2<\/jats:italic> as new vitiligo susceptibility genes and reinforce the hypothesis of a shared genetic mechanism controlling vitiligo and other autoimmune diseases.<\/jats:p>","DOI":"10.1111\/exd.14100","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T20:24:26Z","timestamp":1586809466000},"page":"535-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association study between vitiligo and autoimmune\u2010related genes <i>CYP27B1, REL, TNFAIP3, IL2<\/i> and <i>IL21<\/i>"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-2276","authenticated-orcid":false,"given":"Laysa Toschi","family":"Martins","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences School of Medicine Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba 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Curitiba Brazil"},{"name":"School of Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 Curitiba 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