{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:07:57Z","timestamp":1774278477727,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell adhesion is a complex process that involves multiple molecules on the cell surface (ie cell adhesion molecules [CAMs]), surrounding cells and extracellular matrix (ECM). Repigmentation in vitiligo is dependent on the ECM remodelling and cellular migration, primarily attributed to the transcriptional activation of matrix metalloproteinases (MMPs). In this study, we aimed to demonstrate the role of ETS\u20101 signalling in the regulation of MMPs and CAMs. Therefore, we studied the expression of ETS\u20101, MMPs (MMP\u20102, MMP\u20109) and CAMs including E\u2010cadherin, ITGA\u20101 and ICAM\u20101 in vitiligo (both active and stable) ex vivo. Further, we compared melanocyte morphology and their adhesion towards collagen IV and laminin between control and vitiligo groups in vitro. Also, we silenced ETS\u20101 in melanocytes cultured from control skin and observed post\u2010silencing effect on above\u2010mentioned MMPs and CAMs. We perceived absent ETS\u20101 and significantly reduced CAMs and MMPs in vitiligo compared with normal skin. Scanning electron microscopy (SEM) revealed a translucent material surrounding individual melanocytes in stable vitiligo and controls, whereas active vitiligo melanocytes demonstrated loss of this extracellular substance. Adhesion assays revealed significantly decreased binding of cultured melanocytes to collagen IV and laminin V plates in both stable and active vitiligo. Importantly, ETS\u20101 silencing resulted in significantly reduced expression of CAMs and MMPs. In conclusion, absent ETS\u20101 expression in both stable and active non\u2010segmental vitiligo seems to impede the expression of CAMs, apart from MMPs, probably leading to progressive depigmentation in active disease and absence of spontaneous repigmentation in stable disease.<\/jats:p>","DOI":"10.1111\/exd.14107","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T08:34:12Z","timestamp":1588235652000},"page":"539-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aberrant ETS\u20101 signalling impedes the expression of cell adhesion molecules and matrix metalloproteinases in non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"29","author":[{"given":"Niharika","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"},{"name":"Department of Bioscience and Biotechnology Banasthali Vidyapith Tonk India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Bishnoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakshi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Zoology Panjab University Chandigarh India"},{"name":"Department of Zoology Hindu Girls College Sonepat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-3959","authenticated-orcid":false,"given":"Ravinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Zoology Panjab University Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthu","family":"Sendhil Kumaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Keshavamurthy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Banasthali Vidyapith Tonk India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-0815","authenticated-orcid":false,"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy PGIMER Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12354"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1993.tb00023.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480976"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10039.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10324.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469795"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(81)90326-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10311.x"},{"issue":"25","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"12403","DOI":"10.1016\/S0021-9258(18)37770-6","volume":"263","author":"Corbi A. 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