{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:25:22Z","timestamp":1778509522601,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro\u2010inflammatory cytokines, especially keratinocyte\u2010related VEGF, a potent angiogenic factor. The upregulations of VEGF expression and its secretion promote the formation of new blood vessels and exacerbates rosacea. In this study, radiofrequency (RF) irradiation reduced keratinocyte proliferation in the epidermal layer, the expressions of pro\u2010inflammatory cytokines, angiogenesis\u2010related inflammatory factors and VEGF in our UVB\u2010induced model of rosacea in vitro and in vivo. RF irradiation attenuated VEGF\u2010induced angiogenesis\u2010associated processes such as tube formation, cell migration and endothelial cell proliferation. Notably, blood vessel densities in the skins of UVB\u2010treated mice and rosacea patients were significantly decreased by RF irradiation. These results provide experimental and molecular evidence regarding the effectiveness of RF irradiation for the treatment of rosacea.<\/jats:p>","DOI":"10.1111\/exd.14115","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T21:53:40Z","timestamp":1590011620000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Radiofrequency irradiation attenuates angiogenesis and inflammation in UVB\u2010induced rosacea in mouse skin"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-3991","authenticated-orcid":false,"given":"Myeongjoo","family":"Son","sequence":"first","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology Gachon University College of Medicine  Incheon Korea"},{"name":"Functional Cellular Networks Laboratory College of Medicine Department of Medicine Graduate School and Lee Gil Ya Cancer and Diabetes Institute Gachon University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joonhong","family":"Park","sequence":"additional","affiliation":[{"name":"Maymorning Dermatologic Clinic  Sungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-7139","authenticated-orcid":false,"given":"Seyeon","family":"Oh","sequence":"additional","affiliation":[{"name":"Functional Cellular Networks Laboratory College of Medicine Department of Medicine Graduate School and Lee Gil Ya Cancer and Diabetes Institute Gachon University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-8600","authenticated-orcid":false,"given":"Junwon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology Gachon University College of Medicine  Incheon Korea"},{"name":"Functional Cellular Networks Laboratory College of Medicine Department of Medicine Graduate School and Lee Gil Ya Cancer and Diabetes Institute Gachon University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjung","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology Gachon University College of Medicine  Incheon Korea"},{"name":"Functional Cellular Networks Laboratory College of Medicine Department of Medicine Graduate School and Lee Gil Ya Cancer and Diabetes Institute Gachon University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8917","authenticated-orcid":false,"given":"Donghwan","family":"Kang","sequence":"additional","affiliation":[{"name":"Jeisys Medical Inc.  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