{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:36:25Z","timestamp":1787877385247,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901293"],"award-info":[{"award-number":["30901293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","award":["2012649"],"award-info":[{"award-number":["2012649"]}],"id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic chemotherapy is often the last resort of advanced cutaneous T\u2010cell lymphoma (CTCL). Tumor recurrence and adverse effects of systemic chemotherapy are the main limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to investigate the metabolic alterations in tumor cells after CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone) chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In advanced CTCL, CHOP chemotherapy has no survival benefit and the duration of response is significantly inferior to other canonical treatments. HIF\u20101\u03b1 is significantly elevated in lesions of advanced MF patients as well as tumor cell line Hut78 and tumor xenograft mice model. CHOP therapy also increased glycolytic activities in a HIF\u20101\u03b1\u2010dependent manner. In CTCL xenograft tumor mice model, lesional cells showed a significant increase in IL\u201017F after chemotherapy, shifting toward a Th17 phenotype, which process is also regulated by HIF\u20101\u03b1. Echinomycin, HIF\u20101\u03b1 inhibitor, was co\u2010administered in xenograft tumor mouse models with CHOP and showed a significant reduction in tumor growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CHOP chemotherapy promotes glycolysis and IL\u201017 pathways in a HIF\u20101\u03b1\u2010dependent fashion. Furthermore, HIF\u20101\u03b1 blockade is promising as an accompanying agent in systemic chemotherapy for patients with advanced CTCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.14133","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T17:12:51Z","timestamp":1592932371000},"page":"987-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Systemic chemotherapy promotes HIF\u20101\u03b1\u2010mediated glycolysis and IL\u201017F pathways in cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-498X","authenticated-orcid":false,"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai China"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI 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