{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:48Z","timestamp":1790396628519,"version":"4.1.0"},"reference-count":223,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical hormone therapy with natural or synthetic ligands of nuclear hormone receptors such as glucocorticoids, vitamin D analogues and retinoids has a long and highly successful tradition in dermatology. Yet the dermatological potential of thyroid hormone receptor (TR) agonists has been widely ignored, despite abundant clinical, cell and molecular biology, mouse in vivo, and human skin and hair follicle organ culture data documenting a role of TR\u2010mediated signalling in skin physiology and pathology. Here, we review this evidence, with emphasis on wound healing and hair growth, and specifically highlight the therapeutic potential of repurposing topical L\u2010thyroxine (T4) for selected applications in future dermatological therapy. We underscore the known systemic safety and efficacy profile of T4 in clinical medicine, and the well\u2010documented impact of thyroid hormones on, for example, human epidermal and hair follicle physiology, hair follicle epithelial stem cells and pigmentation, keratin expression, mitochondrial energy metabolism and wound healing. On this background, we argue that short\u2010term topical T4 treatment deserves careful further preclinical and clinical exploration for repurposing as a low\u2010cost, effective and widely available dermatotherapeutic, namely in the management of skin ulcers and telogen effluvium, and that its predictable adverse effects are well\u2010manageable.<\/jats:p>","DOI":"10.1111\/exd.14156","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T22:00:42Z","timestamp":1595109642000},"page":"910-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Topical L\u2010thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-9358","authenticated-orcid":false,"given":"Ralf","family":"Paus","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami FL USA"},{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Manchester Biomedical Research Centre  Manchester UK"},{"name":"Monasterium Laboratory  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-8385","authenticated-orcid":false,"given":"Yuval","family":"Ramot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah Medical Center The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9341-0193","authenticated-orcid":false,"given":"Marjana","family":"Tomic\u2010Canic","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118441213"},{"key":"e_1_2_15_3_1","volume-title":"Treatment of Skin Disease: Comprehensive Therapeutic Strategies","author":"Lebwohl M. G.","year":"2017"},{"key":"e_1_2_15_4_1","volume-title":"Thyroid Hormone","author":"Litwack G.","year":"2018"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30703-1"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620120037007"},{"key":"e_1_2_15_7_1","volume-title":"Rook\u2019s Textbook of Dermatology","author":"Paus R.","year":"2016"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328357b45e"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.1255.111"},{"key":"e_1_2_15_10_1","volume-title":"Williams Textbook of Endocrinology","author":"Sea M.","year":"2019"},{"key":"e_1_2_15_11_1","volume-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","author":"Brunton L.","year":"2017"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.033"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072504774193168"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.1157"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500404"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.08.004"},{"key":"e_1_2_15_17_1","unstructured":"A.Carruthers Cinderella \u2010 And Other Girls Who Lost Their Slippers (Origins of Fairy Tales) Pook Press Alcester Warwickshire UK2015."},{"key":"e_1_2_15_18_1","unstructured":"J.Grimm Grimm W. Kinder\u2010 und Hausm\u00e4rchen Realschulbuchhandlung Berlin1812."},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1915.02570510018005"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.05.007"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1467"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.359"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-19683-6_1"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440601123446"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1574-8"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.1823"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.2108\/zs170011"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0304-5"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.02.016"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.205"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0430-9"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0573"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70111-1"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.02.017"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22045"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.05.009"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0007"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-019-09908-1"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23691.x"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103144200"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.11.4994-5004.2004"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0369"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1529"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-019-04443-x"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7902-8_6"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103284"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-4-815"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0227"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0283"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2016.04.002"},{"key":"e_1_2_15_51_1","first-page":"601361","volume":"2013","author":"Chi H. C.","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.174"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0435"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0557"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0105"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0532"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2235-8"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023825"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65110-3"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00295.x-i1"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64621-4"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26164"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0212"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.361"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03521.x"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321319468"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152484547"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-4-505"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00009-8"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.09.021"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200800121"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0285"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247731"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1024\/0369-8394.91.23.1019"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-93018-8"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14940"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.10.066"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15735"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90232-4"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(07)70145-X"},{"key":"e_1_2_15_81_1","first-page":"179","volume":"44","author":"Ahsan M. K.","year":"1998","journal-title":"J. Med. Invest."},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03408.x"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012405"},{"key":"e_1_2_15_84_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2340\/0001555573102107","volume":"73","author":"Torma H.","year":"1993","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.5.667"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0021-75572007000700011"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.218487"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/355446a0"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2008.00015.x"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0542"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-013-9583-7"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337483"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.8.3168-3179.2004"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1696"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.3.1416"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12614806"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.11.027"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03230"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0306"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121878"},{"key":"e_1_2_15_101_1","volume-title":"Biological, Clocks, Rhythms, and Oscillations: The Theory of Biological Timekeeping","author":"Forger D. B.","year":"2017"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01114.x"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.366"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0115"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.036"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606262200"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063453"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166152"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256251"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/185169a0"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00104"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12343405"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00296.x"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706754104"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.06.002"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16570"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400006"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.005"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.04.004"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb05049.x"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1968fje"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.188268"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1092"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-020-0096-6"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04356.x"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00519.2004"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.01.014"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00217.2011"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19617.x"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.180"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-126417"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.221"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0080"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.016741"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13993"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25357"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.01.001"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23686.x"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.022"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.06.002"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26043"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-07-1251"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.125"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.10.025"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.03.002"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.04.002"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972325"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02250.x"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00019"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.1999.12098449"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04456.x"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212659"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2018.02"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1982.00790530025007"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909800405"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199411001-00001"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90701-0"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1974.tb00201.x"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2012.28.1.17"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197301000-00013"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108137"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13663"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.01.041"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.012"},{"key":"e_1_2_15_165_1","first-page":"407","volume":"25","author":"Mousa S. A.","year":"2006","journal-title":"Int. Angiol."},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130784.90237.4a"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506113113"},{"issue":"14","key":"e_1_2_15_168_1","first-page":"SP607","volume":"24","author":"Kirsner R. S.","year":"2018","journal-title":"Am. J. Manag. Care"},{"key":"e_1_2_15_169_1","first-page":"302","volume":"378","author":"Singer A. J.","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2464-0"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13140-2"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.05.118"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-018-0239-4"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.02.019"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.10.646"},{"key":"e_1_2_15_176_1","author":"Post H.","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7080098"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.10.011"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306923"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00518.x"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.02.012"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4116"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13281"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000513089.75457.22"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.08.035"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.152"},{"key":"e_1_2_15_189_1","author":"Ron\u2010Doitch S.","year":"2020","journal-title":"Exp. Dermatol."},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.031"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.14"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.08.017"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12461"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0267"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092314"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100981"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.04.007"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.286"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2006.00435.x"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700992"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401910106"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.03.056"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13455"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S200471"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.03.007"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.03.017"},{"key":"e_1_2_15_207_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1542"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X10666150904113625"},{"key":"e_1_2_15_209_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00898.x"},{"key":"e_1_2_15_211_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_15_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.10.011"},{"key":"e_1_2_15_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4360"},{"key":"e_1_2_15_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101707"},{"key":"e_1_2_15_215_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84465"},{"key":"e_1_2_15_216_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030715"},{"key":"e_1_2_15_217_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13987"},{"key":"e_1_2_15_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13942"},{"key":"e_1_2_15_219_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021439"},{"key":"e_1_2_15_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.12.028"},{"key":"e_1_2_15_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60782-4"},{"key":"e_1_2_15_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2006.09.008"},{"key":"e_1_2_15_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2013.12.001"},{"key":"e_1_2_15_224_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5128"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.14156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:45:36Z","timestamp":1693554336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":223,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/exd.14156"],"URL":"https:\/\/doi.org\/10.1111\/exd.14156","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}